A technique using micromachined mechanical force sensors to measure the force response of living cells is introduced. The force sensors consist of a probe and flexible beams. The probe is used to indent and stretch the cells, and the flexible beams are used to measure the cell force response. The stiffness of the sensors is designed at several nanonewtons… (More)
Memory and learning in animals are mediated by neurotransmitters that are released from vesicles clustered at the synapse. As a synapse is used more frequently, its neurotransmission efficiency increases, partly because of increased vesicle clustering in the presynaptic neuron. Vesicle clustering has been believed to result primarily from biochemical… (More)
A novel signal enhanced liquid crystal biosensor based on using AuNPs for highly sensitive DNA detection has been developed. This biosensor not only significantly decreases the detection limit, but also offers a simple detection process and shows a good selectivity to distinguish perfectly matched target DNA from two-base mismatched DNA.
Large stretching and un-stretching force response of adherent fibroblasts is measured by micromachined mechanical force sensors. The force sensors are composed of a probe and flexible beams. The probe, functionalized by fibronectin, is used to contact the cells. The flexible beams are the sensing element. The sensors are made of single crystal silicon and… (More)
To everyone who has helped and supported me over the years Acknowledgments First and foremost, I would like to thank my advisor, Ben Kuipers, for his guidance in my research work. I greatly appreciate his stimulation, optimism, encouragement, and patience in my work, without which I would not have been able to make as much progress as I have achieved. His… (More)
In this paper, we propose an algorithm of feature extraction for the composite surface triangle mesh from the stereo lithography (STL) file. By creating a database for quickly determining the dihedral angle threshold of the composite surface mesh, we give a simple feature extraction algorithm based on the dihedral angle threshold. Furthermore, combining… (More)
We will be showing a bioMEMS force sensor and its application in measuring stretch and compression force response of healthy and malaria-infected human red blood cells. The bioMEMS force sensor is made from pure single crystal silicon, and consist of a probe and flexible beams. The probe is used to contact, indent and stretch the cells, and the flexible… (More)