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In multicellular organisms, morphogenesis is a highly coordinated process that requires dynamically regulated adhesion between cells. An excellent example of cellular morphogenesis is the formation of the neural tube from the flattened epithelium of the neural plate. Cysteine-rich motor neuron protein 1 (CRIM1) is a single-pass (type 1) transmembrane(More)
We have annotated and analyzed sequences from the CYP2ABFGST gene cluster for the chimpanzee and the Rhesus macaque, and compared them in detail to the complete map of the syntenic human cluster. While the macaque cluster has accumulated substantial differences in gene number and organization relative to the other two species, the chimpanzee cluster has(More)
BACKGROUND Duchenne Muscular Dystrophy (DMD) is a recessive X-linked form of muscular dystrophy. Steroid therapy has clinical benefits for DMD patients, but the mechanism remains unclear. OBJECTIVE This study was designed to identify mRNAs and microRNAs regulated in Duchenne Muscular Dystrophy patients prior to and after steroid therapy. METHODS Genome(More)
Individuals with neuromuscular disease show a wide spectrum of muscle pathology. To test the hypothesis that the immune response to trivalent inactivated influenza vaccine is potentially inadequate when given intramuscularly into a fibrosed muscle, this prospective randomized study compared the immunogenicity and safety of the standard intramuscular versus(More)
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