Shengtian Yang

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Combined verification using 1-D proton and HSQC has been proved to be quite successful; the acquisition time of HSQC spectra, however, can be limiting in its high-throughput applications. The replacement with Hadamard HSQC can significantly enhance the throughput. We hereby propose a protocol to optimize the grouping of the predicted carbon chemical shifts(More)
The problem of finding good linear codes for joint source-channel coding (JSCC) is investigated in this paper. By the code-spectrum approach, it has been proved in the authors' previous paper that a good linear code for the authors' JSCC scheme is a code with a good joint spectrum, so the main task in this paper is to construct linear codes with good joint(More)
We have discovered a novel class of nonsteroidal pyrazoline antagonists of the mineralocorticoid receptor (MR) that show excellent potency and selectivity against other nuclear receptors. Early analogues were poorly soluble and had a propensity to inhibit the hERG channel. Remarkably, both of these challenges were overcome by incorporation of a single(More)
The thiophene moiety is considered a structural alert in molecular design in drug discovery, largely because several thiophene-containing drugs, including tienilic acid and suprofen, have been withdrawn from the market because of toxicities. Reactive thiophene intermediates, activated via sulfur oxidation or ring epoxidation, are possible culprits for these(More)
Riparian ecosystems have critical impacts on controlling the non-point source pollution and maintaining the health of aquatic ecosystems. In this study, a process oriented soil denitrification model was extended with algorithms from a simple nitrogen (N) cycle model and coupled to land surface remote sensing data to enhance its performance in spatial and(More)
Microsomal prostaglandin E(2) synthase-1 (mPGES-1) is a novel therapeutic target for the treatment of inflammation and pain. In the preceding letter, we detailed the discovery of clinical candidate PF-04693627, a potent mPGES-1 inhibitor possessing a novel benzoxazole structure. While PF-04693627 was undergoing further preclinical profiling, we sought to(More)
Nonimmunosuppressive cyclophilin inhibitors have demonstrated efficacy for the treatment of hepatitis C infection (HCV). However, alisporivir, cyclosporin A, and most other cyclosporins are potent inhibitors of OATP1B1, MRP2, MDR1, and other important drug transporters. Reduction of the side chain hydrophobicity of the P4 residue preserves cyclophilin(More)
We derive an upper bound on the average MAP decoding error probability of random linear SW codes for arbitrary correlated stationary memoryless sources defined on Galois fields. By using this tool, we analyze the performance of SW codes based on LDPC codes and random permutations, and show that under some conditions, all but a diminishingly small proportion(More)
The average weight distribution of a regular low-density parity-check (LDPC) code ensemble over a finite field is thoroughly analyzed. In particular, a precise asymptotic approximation of the average weight distribution is derived for the small-weight case, and a series of fundamental qualitative properties of the asymptotic growth rate of the average(More)
We think about the problem of reliable transmission of information over AWGN channels using rateless codes. We introduce a new family of rateless codes, named the accumulate rateless (AR) codes, which is easy to construct as traditional LT codes but has better performance and lower complexity. We investigate the performance of AR codes over AWGN channels,(More)