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Recent studies of the association between the metabotropic glutamate receptor 3 gene (GRM3) and schizophrenia have produced conflicting results, although GRM3 is a promising candidate gene. Fujii et al. found a single nuclear polymorphism (SNP) for within this gene, rs1468412 to have a positive association to schizophrenia in Japanese patients. To(More)
Simulation has many advantages in modeling complex systems to facilitate decision making. In this research, an integrated computer system will be developed which incorporates an agent-based discrete event simulator, a geographic information system, a rule base, and interactive databases in addition to interfaces and other supporting components. The modules(More)
Antipsychotic drugs exert both therapeutic and adverse effects through dopamine D2 receptor (DRD2) antagonism. Genetic variants of this receptor may be responsible for individual variations in neuroleptic response and may therefore be useful in predicting response. In this study we evaluated the role of six polymorphisms of the DRD2 gene in 125(More)
This report is designed to dissect the detail molecular mechanism by which dihydroartemisinin (DHA), a derivative of artemisinin, induces apoptosis in human hepatocellular carcinoma (HCC) cells. DHA induced a loss of the mitochondrial transmemberane potential (ΔΨm), release of cytochrome c, activation of caspases, and externalization of phosphatidylserine(More)
Members of the amino acid transporters (AATs) gene family transported amino acid across cellular membranes and participated in various aspects of normal plant growth and developmental processes as well as environmental responses. To date, no overall analysis or expression profiling of the AAT gene family in Populus has been reported. An investigation of the(More)
Using Chinese National Knowledge Infrastructure as the data resource, this paper searched some papers about open access (OA). Some Visual Basic for Applications programs were developed to generate the co-word matrix, compute the E-index value of keywords as well as the density and centrality of thematic clusters. Callon’s clustering method was also used to(More)
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