Shengming Liu

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RATIONALE The prevalence of chronic obstructive pulmonary disease (COPD) in China is largely unknown. OBJECTIVES To obtain the COPD prevalence in China through a large-population, spirometry-based, cross-sectional survey of COPD. METHODS Urban and rural population-based cluster samples were randomly selected from seven provinces/cities. All residents 40(More)
BACKGROUND There is increasing evidence for a possible association between chronic obstructive pulmonary disease (COPD) and the use of biomass fuels for cooking and heating in developing countries. Data on the prevalence of COPD and objective measurements of indoor pollution from biomass fuel have not been widely available from China. A study was undertaken(More)
OBJECTIVE To evaluate the effects of a community based integrated intervention for early prevention and management of chronic obstructive pulmonary disease (COPD) in China. DESIGN Cluster randomised controlled trial. SETTING Eight healthcare units in two communities. PARTICIPANTS Of 1062 people aged 40-89, 872 (101 with COPD and 771 without COPD) who(More)
Fungal histidine kinases (HKs) are involved in osmotic and oxidative stress responses, hyphal development, fungicide sensitivity and virulence. Members of HK class III are known to signal through the high-osmolarity glycerol mitogen-activated protein kinase (HOG MAPK). In this study, we characterized the Shk1 gene (SS1G_12694.3), which encodes a putative(More)
BACKGROUND Cigarette smoking is a major environmental contributor to COPD, but understanding its epigenetic regulation of oxidative genes involved in the pathogenesis of COPD remains elusive. METHODS We analyzed DNA methylation on glutamate-cysteine ligase catalytic subunit (GCLC), glutathione S-transferase M1 (GSTM1), glutathione S-transferase P1(More)
OBJECTIVE AND BACKGROUND Increasing evidence suggests that low-dose theophylline has anti-inflammatory benefits and is safe in the treatment of COPD. This study aims to evaluate the efficacy and safety of low-dose, slow-release oral theophylline administered over a 1-year period in patients with COPD. METHODS A randomized, double-blind, parallel-group,(More)
The effects of luteolin on the proliferation of A549 cells were evaluated by MTT and clone formation assays. DNA ploidy and apoptotic cell percentage were calculated by flow cytometry. The expression of Bax, Bcl-xl, Bcl-2, Mcl-1, caspase-9, caspase-3, and PARP was analyzed by Western blotting. The membrane potential of mitochondria was detected by JC-1(More)
BACKGROUND AND OBJECTIVES The importance of genetic susceptibility in COPD has not been determined. The aim of this study was to investigate the association between susceptibility to COPD and polymorphisms in the Clara cell 16 kDa secretory protein (CC16), 8-hydroxy-guanine glycosylase (OGG1) and glutamatecysteine ligase catalytic subunit (GCLC) genes in a(More)
Based on the vector similarity theory, a new method of multi-plan optimization is proposed in this paper. The paper discusses the optimization steps of the method in detail. Finally, an example show that the effectiveness and practicality of this method by the comparison of decision results among the vector similarity method, the TOPSIS method, the angle(More)
BACKGROUND Chronic obstructive pulmonary disease (COPD) is a commonly reported cause of death and associated with smoking. However, COPD mortality is high in poor countries with low smoking rates. Spirometric restriction predicts mortality better than airflow obstruction, suggesting that the prevalence of restriction could explain mortality rates attributed(More)