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Bmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16Ink4a and p19Arf senescence pathways.

• Anna Victoria Molofsky, Shenghui He, Mohammad Bydon, Sean J Morrison, Ricardo Pardal
• Genes & development
• 2005

Bmi-1 is required for the post-natal maintenance of stem cells in multiple tissues including the central nervous system (CNS) and peripheral nervous system (PNS). Deletion of Ink4a or Arf from… (More)

Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing.

• Anna Victoria Molofsky, Shalom G Slutsky, +5 authors Sean J Morrison
• Nature
• 2006

Mammalian ageing is associated with reduced regenerative capacity in tissues that contain stem cells. It has been proposed that this is at least partially caused by the senescence of progenitors with… (More)

Haematopoietic stem cells do not asymmetrically segregate chromosomes or retain BrdU.

• Mark J. Kiel, Shenghui He, +5 authors Sean J Morrison
• Nature
• 2007

Stem cells are proposed to segregate chromosomes asymmetrically during self-renewing divisions so that older ('immortal') DNA strands are retained in daughter stem cells whereas newly synthesized… (More)

Enhanced purification of fetal liver hematopoietic stem cells using SLAM family receptors.

• Injune Kim, Shenghui He, Omer Hinc Yilmaz, Mark J. Kiel, Sean J Morrison
• Blood
• 2006

Although adult mouse hematopoietic stem cells (HSCs) have been purified to near homogeneity, it remains impossible to achieve this with fetal HSCs. Adult HSC purity recently has been enhanced using… (More)

Enteric glia are multipotent in culture but primarily form glia in the adult rodent gut.

• Nancy M. Joseph, Shenghui He, Elsa Quintana, Yun-Gi Kim, Gabriel Núñez, Sean J Morrison
• The Journal of clinical investigation
• 2011

It is unclear whether neurogenesis occurs in the adult mammalian enteric nervous system (ENS). Neural crest-derived cells capable of forming multilineage colonies in culture, and neurons and glia… (More)

Mechanisms of stem cell self-renewal.

• Shenghui He, Daisuke Nakada, Sean J Morrison
• Annual review of cell and developmental biology
• 2009

Self-renewal is the process by which stem cells divide to make more stem cells, perpetuating the stem cell pool throughout life. Self-renewal is division with maintenance of the undifferentiated… (More)

Senescence in Health and Disease.

• Shenghui He, Norman E Sharpless
• Cell
• 2017

Many cellular stresses activate senescence, a persistent hyporeplicative state characterized in part by expression of the p16INK4a cell-cycle inhibitor. Senescent cell production occurs throughout… (More)

Bmi-1 over-expression in neural stem/progenitor cells increases proliferation and neurogenesis in culture but has little effect on these functions in vivo.

• Shenghui He, Toshihide Iwashita, Johanna Buchstaller, Anna Victoria Molofsky, Dafydd Gareth Thomas, Sean J Morrison
• Developmental biology
• 2009

The polycomb gene Bmi-1 is required for the self-renewal of stem cells from diverse tissues, including the central nervous system (CNS). Bmi-1 expression is elevated in most human gliomas,… (More)

Sox17 expression confers self-renewal potential and fetal stem cell characteristics upon adult hematopoietic progenitors.

• Shenghui He, Injune Kim, M. Lim, Sean J Morrison
• Genes & development
• 2011

A key question concerns the mechanisms that determine temporal identity in stem cells. Fetal hematopoietic stem cells (HSCs) differ from adult HSCs in terms of gene expression profile, surface marker… (More)

Research on Knowledge Management in Enterprise

• Shenghui He, Chaoyang Xiang, Lei Chen
• 2009 International Symposium on Intelligent…
• 2009

In practice area, with the globalization as well as the knowledge economy era's coming, enterprises are realizing the importance of knowledge management. More and more enterprises started… (More)

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