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Tuberculosis (TB) remains to be a global health problem. New drugs are badly needed to drastically reduce treatment time and overcome some of the challenges with tuberculosis treatment, such as multi-drug resistant (MDR) strain infected patients or tuberculosis/HIV co-infected patients. The essentiality of mycobacterial aromatic amino acid biosynthesis(More)
Tuberculosis, caused by Mycobacterium tuberculosis, continues to be one of the leading infectious diseases to humans. It is urgent to discover novel drug targets for the development of antitubercular agents. The 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway for isoprenoid biosynthesis has been considered as an attractive target for the discovery of(More)
—With the rapid development of high-speed railway (HSR), how to provide the passengers with multimedia services has attracted increasing attention. A key issue is to develop an effective scheduling algorithm for multiple services with different quality of service (QoS) requirements. In this paper, we investigate the downlink service scheduling problem in(More)
In this paper, we consider delay-aware fair downlink scheduling with heterogeneous packet arrivals and delay requirements for a relay-assisted high-speed railway (HSR) network. Data packets from multi-users requests are delivered via the two-hop network architecture to achieve a high data transmission rate instead of direct transmission. Our objective is to(More)
This paper considers an energy-efficient packet scheduling problem over quasi-static block fading channels. The goal is to minimize the total energy for transmitting a sequence of data packets under the first-in-first-out rule and strict delay constraints. Conventionally, such design problem is studied under the assumption that the packet transmission rate(More)
Trehalose-6-phosphate phosphatase is an enzyme strictly essential for the growth of mycobacteria. Subcellular fractionation of Mycobacterium tuberculosis and M. bovis bacillus Calmette-Guérin (BCG) located the trehalose-6-phosphate phosphatase in the cell wall and membrane fractions. Trehalose-6-phosphate phosphatase induced an increased Th1-type immune(More)
—In this paper, we investigate the delay-aware dynamic resource management problem for multi-service transmission in high-speed railway wireless communications, with a focus on resource allocation among the services and power control along the time. By taking account of average delay requirements and power constraints, the considered problem is formulated(More)
Tuberculosis (TB) continues to be a major cause of morbidity and mortality worldwide. The increasing emergence and spread of drug-resistant TB poses a significant threat to disease control and calls for the urgent development of new drugs. The tryptophan biosynthetic pathway plays an important role in the survival of Mycobacterium tuberculosis. Thus,(More)