Shengchao Li

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There are two common designs for association mapping of complex diseases: case-control and family-based designs. A case-control sample is more powerful to detect genetic effects than a family-based sample that contains the same numbers of affected and unaffected persons, although additional markers may be required to control for spurious association. When(More)
A two-dimensional space–time pilot-symbol assisted demodulation system is proposed in this paper. Since complex scattering environments can produce nontrivial space–time correlation characteristics, this paper proposes coherent demodulation by estimating the fading channel distortion using pilot observations across both space and time. The optimum(More)
Identification of disease variants via homozygosity mapping and investigation of the effects of genome-wide homozygosity regions on traits of biomedical importance have been widely applied recently. Nonetheless, the existing methods and algorithms to identify long tracts of homozygosity (TOH) are not able to provide efficient and rigorous regions for(More)
Finite delay breadth-first equalizer for inter-symbol interference (ISI) channels is presented. Based on the maximum signal-to-noise ratio (SNR) criterion, optimal structures for all breadth-first equalizers are found. Recursive algorithms for the Ungerboeck and the Forney structures are developed, which are parallel to the structures of the well-known(More)
To evaluate associations by EGFR mutation status for lung adenocarcinoma risk among never-smoking Asian women, we conducted a meta-analysis of 11 loci previously identified in genome-wide association studies (GWAS). Genotyping in an additional 10,780 never-smoking cases and 10,938 never-smoking controls from Asia confirmed associations with eight known(More)
We propose a new rule, loop reversal, in block diagram and signal flow graph manipulation (or transformation) that leads to equivalent block diagrams or signal flow graphs from existing ones. It is known that “algebraic loops” can exist in some systems, where different choices of causality end up with different yet equivalent block diagrams or(More)
Genome-wide association studies (GWAS) of lung cancer in Asian never-smoking women have previously identified six susceptibility loci associated with lung cancer risk. To further discover new susceptibility loci, we imputed data from four GWAS of Asian non-smoking female lung cancer (6877 cases and 6277 controls) using the 1000 Genomes Project (Phase 1(More)
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