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Lactuca indica (Compositae) is an edible wild vegetable, used as a folk medicine in anti-inflammatory, antibacterial, and other medications in Asia. This is the first scientific evaluation of the chemopreventive therapeutic properties of L. indica using five antioxidation assay systems. An extract from L. indica was found to possess significant free radical(More)
In this study, we investigated the cytoprotective effects of antcin C, a steroid-like compound isolated from Antrodia cinnamaomea against AAPH-induced oxidative stress and apoptosis in human hepatic HepG2 cells. Pretreatment with antcin C significantly protects hepatic cells from AAPH-induced cell death through the inhibition of ROS generation. Furthermore,(More)
Crassocephalum rabens (Asteraceae) is a popular anti-inflammatory folk medicine and food supplement. We investigated the cancer chemopreventive bioactivity of C. rabens phytocompounds in vitro and in vivo using cell- and gene-based bioassays and a mouse B16 melanoma model. The bioactive glyceroglycolipid(More)
Flavonoids are abundant in the leaves, flowers, branches, bark, and heartwood of Acacia confusa Merr. (Leguminosae), and the extracts have been found to have strong antioxidant activities. Flavonols are the major class of flavonoids found in A. confusa. The full-length gene (designated as AcFLS) contains an open reading frame of 996 nucleotides encoding 331(More)
In this study, chemical compositions of hydrodistilled essential oil and anti-inflammatory activities from the twigs of Cinnamomum osmophloeum Kaneh. were investigated for the first time. The chemical constituents of the twig essential oil were further analyzed by GC-MS and they were found to be L-bornyl acetate (15.89%), caryophyllene oxide (12.98%),(More)
Cinnamomum osmophloeum Kaneh is one of the hardwood species indigenous to Taiwan that possesses significant antifungal activity. To examine the antifungal activity of leaf essential oils and dominant constituents from C. osmophloeum, the essential oils of leaves from three clones (A, B, and C) collected from Haw-Lin experimental forest were extracted and(More)
Androgen receptor (AR) is the main therapeutic target for treatment of metastatic prostate cancers (PCa). As recurrent tumors restore AR activity independent of hormones, new therapies that abolish AR activity have been sought to prevent or delay the emergence of ablation-resistant disease. Here, we report that a novel abietane diterpene,(More)
AIM To determine the active ingredient of Niuchangchih (Antrodia camphorata) responsible for its anti-inflammatory effects and the relevant molecular mechanisms. METHODS Five major antcins (A, B, C, H, and K) were isolated from fruiting bodies of Niuchangchih. Structural similarity between the antcins and 2 glucocorticoids (cortisone and dexamethasone)(More)
Epithelial-to-mesenchymal transition (EMT) is a crucial event involved metastasis of certain tumors. Thus, identifying chemical agents that can block EMT is highly warranted for the development of anti-cancer chemoprevention/chemotherapies. In this study, we found that Antrodin C (ADC), a maleimide derivative isolated from Antrodia cinnamomea health food(More)
Litsea cubeba (Lauraceae) is woody plant endemic to Taiwan that is traditionally used as a spice. In the current study, several behavioral analyses were performed to evaluate the neuropharmacological activity of the essential fruit oil of L. cubeba in ICR mice. Oral administration of 100, 300 and 500 mg/kg of L. cubeba fruit oil significantly prolonged(More)