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OBJECTIVE To investigate changes of autophagy after traumatic brain injury (TBI) and its possible role. METHODS Rat TBI model was established by controlled cortical injury system. Autophagic double membrane structure was detected by transmission electronic microscope. Microtubule-associated protein 1 light chain 3 (LC3) and Beclin 1 were also used to(More)
OBJECTIVE To study the expression of cathepsin-B and -D in different time point after traumatic brain injury. METHODS Traumatic brain injury (TBI) model was established on rats, cathepsin-B and cathepsin-D immunofluorescence staining and confocal microscope analysis were performed. Positive cells were counted by confocal microscope and image analysis(More)
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