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Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB.

• Naohiro Inohara, Takeyoshi Koseki, +8 authors Gabriel Núñez
• The Journal of biological chemistry
• 1999

Ced-4 and Apaf-1 belong to a major class of apoptosis regulators that contain caspase-recruitment (CARD) and nucleotide-binding oligomerization domains. Nod1, a protein with an NH2-terminal… (More)

ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases.

• Takeyoshi Koseki, Naohiro Inohara, Sheng-hong Chen, Gabriel Núñez
• Proceedings of the National Academy of Sciences…
• 1998

We have identified and characterized ARC, apoptosis repressor with caspase recruitment domain (CARD). Sequence analysis revealed that ARC contains an N-terminal CARD fused to a C-terminal region rich… (More)

harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-X(L).

• Naohiro Inohara, Liyun Ding, Sheng-hong Chen, Gabriel Núñez
• The EMBO journal
• 1997

Programmed cell death is essential in organ development and tissue homeostasis and its deregulation is associated with the development of several diseases in mice and humans. The precise mechanisms… (More)

CIDE, a novel family of cell death activators with homology to the 45 kDa subunit of the DNA fragmentation factor.

• Naohiro Inohara, Takeyoshi Koseki, Sheng-hong Chen, Xiaosheng Wu, Gabriel Núñez
• The EMBO journal
• 1998

DFF45 is a subunit of the DNA fragmentation factor (DFF) that is cleaved by caspase-3 during apoptosis. However, the mechanism by which DFF45 regulates apoptotic cell death remains poorly understood.… (More)

Rab8b and its interacting partner TRIP8b are involved in regulated secretion in AtT20 cells.

• Sheng-hong Chen, Mui Cheng Liang, J N Chia, Johnny K. Ngsee, Anthony Eugene Ting
• The Journal of biological chemistry
• 2001

Rab proteins are a family of small GTPases that regulate intracellular vesicle traffic. Rab8b, because of its homology with Rab8, has been suggested to function in vesicle transport to the plasma… (More)

Direct binding of SAS-6 to ZYG-1 recruits SAS-6 to the mother centriole for cartwheel assembly.

• Molly M Lettman, Yao Liang Wong, +6 authors Karen Oegema
• Developmental cell
• 2013

Assembly of SAS-6 dimers to form the centriolar cartwheel requires the ZYG-1/Plk4 kinase. Here, we show that ZYG-1 recruits SAS-6 to the mother centriole independently of its kinase activity; kinase… (More)

CLARP, a death effector domain-containing protein interacts with caspase-8 and regulates apoptosis.

• Naohiro Inohara, Takeyoshi Koseki, Yun Hu, Sheng-hong Chen, Gabriel Núñez
• Proceedings of the National Academy of Sciences…
• 1997

We have identified and characterized CLARP, a caspase-like apoptosis-regulatory protein. Sequence analysis revealed that human CLARP contains two amino-terminal death effector domains fused to a… (More)

RICK, a novel protein kinase containing a caspase recruitment domain, interacts with CLARP and regulates CD95-mediated apoptosis.

• Naohiro Inohara, Luis Del Peso, Takeyoshi Koseki, Sheng-hong Chen, Gabriel Núñez
• The Journal of biological chemistry
• 1998

Signaling through the CD95/Fas/APO-1 death receptor plays a critical role in the homeostasis of the immune system. RICK, a novel protein kinase that regulates CD95-mediated apoptosis was identified… (More)

Inhibition of the transcription factors AP-1 and NF-kappaB in CD4 T cells by peroxisome proliferator-activated receptor gamma ligands.

• Ping Wang, Per O Anderson, Sheng-hong Chen, Kajsa Paulsson, Hans Olov Sjögren, Suling Li
• International immunopharmacology
• 2001

The peroxisome proliferator-activated receptor gamma (PPARgamma), a member of the nuclear hormone receptor superfamily, is essential for adipocyte differentiation and glucose homeostasis. PPARgamma… (More)

Diva, a Bcl-2 homologue that binds directly to Apaf-1 and induces BH3-independent cell death.

• Naohiro Inohara, Tania S. Gourley, +7 authors Gabriel Núñez
• The Journal of biological chemistry
• 1998

We have identified and characterized Diva, which is a novel regulator of apoptosis. Sequence analysis revealed that Diva is a member of the Bcl-2 family of proteins containing Bcl-2 homology domain… (More)

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