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- Takeyoshi Koseki, Naohiro Inohara, Sheng-hong Chen, Gabriel Núñez
- Proceedings of the National Academy of Sciences…
- 1998
We have identified and characterized ARC, apoptosis repressor with caspase recruitment domain (CARD). Sequence analysis revealed that ARC contains an N-terminal CARD fused to a C-terminal region rich… (More)
- Naohiro Inohara, Takeyoshi Koseki, +8 authors Gabriel Núñez
- The Journal of biological chemistry
- 1999
Ced-4 and Apaf-1 belong to a major class of apoptosis regulators that contain caspase-recruitment (CARD) and nucleotide-binding oligomerization domains. Nod1, a protein with an NH2-terminal… (More)
- Naohiro Inohara, Takeyoshi Koseki, Sheng-hong Chen, Xiaosheng Wu, Gabriel Núñez
- The EMBO journal
- 1998
DFF45 is a subunit of the DNA fragmentation factor (DFF) that is cleaved by caspase-3 during apoptosis. However, the mechanism by which DFF45 regulates apoptotic cell death remains poorly understood.… (More)
- Naohiro Inohara, Liya Ding, Sheng-hong Chen, Gabriel Núñez
- The EMBO journal
- 1997
Programmed cell death is essential in organ development and tissue homeostasis and its deregulation is associated with the development of several diseases in mice and humans. The precise mechanisms… (More)
- Sheng-hong Chen, Mui Cheng Liang, J N Chia, Johnny Kuan Ngsee, Anthony E. Ting
- The Journal of biological chemistry
- 2001
Rab proteins are a family of small GTPases that regulate intracellular vesicle traffic. Rab8b, because of its homology with Rab8, has been suggested to function in vesicle transport to the plasma… (More)
- Naohiro Inohara, Luis Del Peso, Takeyoshi Koseki, Sheng-hong Chen, Gabriel Núñez
- The Journal of biological chemistry
- 1998
Signaling through the CD95/Fas/APO-1 death receptor plays a critical role in the homeostasis of the immune system. RICK, a novel protein kinase that regulates CD95-mediated apoptosis was identified… (More)
- Naohiro Inohara, Tania S. Gourley, +7 authors Gabriel Núñez
- The Journal of biological chemistry
- 1998
We have identified and characterized Diva, which is a novel regulator of apoptosis. Sequence analysis revealed that Diva is a member of the Bcl-2 family of proteins containing Bcl-2 homology domain… (More)
- Naohiro Inohara, Takeyoshi Koseki, Yun Xiang Hu, Sheng-hong Chen, Gabriel Núñez
- Proceedings of the National Academy of Sciences…
- 1997
We have identified and characterized CLARP, a caspase-like apoptosis-regulatory protein. Sequence analysis revealed that human CLARP contains two amino-terminal death effector domains fused to a… (More)
- Molly M Lettman, Yao Liang Wong, +6 authors Karen Oegema
- Developmental cell
- 2013
Assembly of SAS-6 dimers to form the centriolar cartwheel requires the ZYG-1/Plk4 kinase. Here, we show that ZYG-1 recruits SAS-6 to the mother centriole independently of its kinase activity; kinase… (More)
- Marcus Bustamante Smolka, Sheng-hong Chen, +6 authors Huilin Zhou
- The Journal of cell biology
- 2006
The DNA damage checkpoint kinase Rad53 is important for the survival of budding yeast under genotoxic stresses. We performed a biochemical screen to identify proteins with specific affinity for the… (More)