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Jatrophane Diterpenoids as Modulators of P-Glycoprotein-Dependent Multidrug Resistance (MDR): Advances of Structure-Activity Relationships and Discovery of Promising MDR Reversal Agents.
TLDR
A jatrophane library containing two series of compounds was established to screen for P-glycoprotein (Pgp)-dependent MDR modulators, which showed that modifications beyond just increasing the lipophilicity of this class of Pgp inhibitors are beneficial to the activity.
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Prenylated coumarins: natural phosphodiesterase-4 inhibitors from Toddalia asiatica.
TLDR
Bioassay-guided fractionation of the ethanolic extract of the roots of Toddalia asiatica led to the isolation of seven new prenylated coumarins (1-7) and 14 known analogues (8-21), which represent an unusual group of phenylpropenoic acid-coupled prenylonins.
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Enantiomeric neolignans and sesquineolignans from Jatropha integerrima and their absolute configurations
Two pairs of new sesquineolignan enantiomers, (±)-jatrointelignans A and B (1a/1b and 2a/2b), one pair of new neolignan enantiomers, (±)-jatrointelignan D (4a/4b), and two new neolignans,…
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Psiguajadials A–K: Unusual Psidium Meroterpenoids as Phosphodiesterase-4 Inhibitors from the Leaves of Psidium guajava
TLDR
11 new Psidium meroterpenoids, psiguajadials A–K (1–11), along with 17 known ones (12–28), were isolation and their structures and absolute configurations were elucidated by spectroscopic methods and comparison of experimental and calculated ECD.
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Natural thioredoxin reductase inhibitors from Jatropha integerrima
Nine new diterpenoids, jatrointelones A–I (1–9), including seven lathyranes (1–7) and two jatropholanes (8 and 9), along with 12 known analogues (10–21) were isolated from the trunks of Jatropha…
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Anti-inflammatory sesquiterpenoids from the Traditional Chinese Medicine Salvia plebeia: Regulates pro-inflammatory mediators through inhibition of NF-κB and Erk1/2 signaling pathways in LPS-induced…
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Diterpenoids from Euphorbia royleana reverse P-glycoprotein-mediated multidrug resistance in cancer cells.
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Development of a novel berberine-mediated mitochondria-targeting nano-platform for drug-resistant cancer therapy.
TLDR
The results confirmed that alkylated berberines can be exploited as mitochondrial-targeting ligands to overcome cancer multi-drug resistance, further advancing the research on active targeting of liposome delivery systems in the treatment of resistant cancer.
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Neuroprotective polyhydroxypregnane glycosides from Cynanchum otophyllum
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Nitric oxide inhibitory xanthones from the pericarps of Garcinia mangostana.
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