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Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients
Baicalin and baicalein, two ingredients of Shuanghuanglian, were characterized as the first noncovalent, nonpeptidomimetic inhibitors of SARS-CoV-2 3CLpro and exhibited potent antiviral activities in a cell-based system.
Discovery of baicalin and baicalein as novel, natural product inhibitors of SARS-CoV-2 3CL protease in vitro
Baicalin and baicalein were identified as the first non-covalent, non-peptidomimetic inhibitors of SARS-CoV-2 3CLpro and exhibited potent antiviral activities in a cell-based system.
Activation of AMPK by Bitter Melon Triterpenoids Involves CaMKKβ
It is proposed that CaMKKβ is a key upstream kinase for BMT-induced activation of AMPK, a leading anti-diabetic drug target.
Identification of pyrogallol as a warhead in design of covalent inhibitors for the SARS-CoV-2 3CL protease
The discovery of myricetin, a flavonoid found in many food sources, is described, as a non-peptidomimetic and covalent inhibitor of the SARS-CoV-2 3CLpro, highlighting the potential of pyrogallol as an alternative warhead in design of targeted covalant ligands.
Polyoxypregnane steroids from the stems of Marsdenia tenacissima.
A new polyoxypregnane aglycone, tenacigenin D (1), and seven new C21 steroid glycosides, tenacissimosides D-J (2-8), were isolated from the stems of Marsdenia tenacissima. Their structures were…
Diterpenoids from the flowers of Rhododendron molle.
Two new kalmane-type diterpenoids, rhodomolleins XXIII (7) and XXIV (8), together with seven known compounds, were isolated from the flowers of Rhododendron molle collected in Guangxi Province, China.
Anti-inflammatory Inositol Derivatives from the Whole Plant of Inula cappa.
Twelve new inositol derivatives, classified into myoinositol and l-inositol types, along with five known analogues were isolated from the whole plant of Inula cappa and showed anti-inflammatory activities against the production of NO in RAW264.
Humulane-type sesquiterpenoids from Pilea cavaleriei subsp. crenata.
Nine new, uncommon humulane-type sesquiterpenoids (1, 2, 4, 6-11), together with two known derivatives, were isolated from extracts of the plant Pilea cavaleriei subsp. crenata. The structures of…
Limonoids and triterpenoids from the stem bark of Melia toosendan.
Four new limonoids (1, 3, 4, 6), named meliatoosenins A-D, eight new euphane- and tirucallane-type triterpenoids (8-15), and 13 known compounds have been isolated from the stem bark of Melia toosendan.