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Global mapping of translation initiation sites in mammalian cells at single-nucleotide resolution
Global translation initiation sequencing is presented, applying in parallel the ribosome E-site translation inhibitors lactimidomycin and cycloheximide to achieve simultaneous detection of both initiation and elongation events on a genome-wide scale. Expand
Decoding Human Cytomegalovirus
The results reveal an unanticipated complexity to the HCMV coding capacity and illustrate the role of regulated changes in transcript start sites in generating this complexity. Expand
Diterpenoids from Isodon species and their biological activities.
Isodon species (Labiatae) are widely distributed plants, many of which are used in folk medicine, and have received considerable phytochemical and biological attention over the past twenty years. Expand
Compounds from Kadsura heteroclita and related anti-HIV activity.
Phytochemical investigation of the stems of Kadsura heteroclita led to isolation of 16 compounds, including the triterpenoid named longipedlactone J (2), and two dibenzocyclooctadiene type lignansExpand
Kadcoccilactones A-J, triterpenoids from Kadsura coccinea.
This is the first report on nortriterpenoids (2, 4-6, 8-10) from the genus Kadsura, and the structures were elucidated by spectroscopic evidence and single-crystal X-ray diffraction analysis. Expand
Genome Sequence of the Milbemycin-Producing Bacterium Streptomycesbingchenggensis
The complete genome sequence of S. bingchenggensis is reported, which should enable us to understand the biosynthesis of these structurally intricate antibiotics better and facilitate rational improvement of this strain to increase their titers. Expand
SHP2 is a target of the immunosuppressant tautomycetin.
The data support the notion that SHP2 is a cellular target for TTN and provide a potential mechanism for the immunosuppressive activity of TTN, and the structure furnishes molecular insights upon which therapeutics targetingSHP2 can be developed on the basis of the TTN scaffold. Expand
Nortriterpenoids and lignans from Schisandra sphenanthera.
Nortriterpenoids, sphenadilactone C (1) and sphenasin A (2), together with four known lignans (3-6), were isolated from the leaves and stems of Schisandra sphenanthera and showed weak anti-HIV-1 activity. Expand
Lignans from Kadsura angustifolia.
Phytochemical investigation of Kadsura angustifolia led to the isolation and identification of 26 lignans and two triterpenoids, including 11 new lignan named kadangustins A-K ( 1- 11), which were elucidated by analysis of spectroscopic data. Expand
Triterpenoids from the Schisandraceae family.
This review covers the structures, proposed biosynthetic pathways, total synthesis and biological activities of these and other triterpenoids from the plants of the family Schisandraceae. Expand