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Acylated iridoids with cytotoxicity from Valeriana jatamansi.
Thirteen new acylated iridoids, jatamanvaltrates A-M (1-13), together with nine known valepotriates (14-22), were isolated from the whole plants of Valeriana jatamansi and tested for their cytotoxicity against lung adenocarcinoma, metastatic prostate cancer, colon cancer, and hepatoma cell lines.
Iridoids and lignans from Valeriana jatamansi.
Thirteen new iridoids including seven iridolactones, jatamanins A-M (1-13), and a new lignan, (+)-9'-isovaleroxylariciresinol (14), together with seven known iridoids and 13 lignans were obtained…
Characterization of chlorinated valepotriates from Valeriana jatamansi.
Three decomposition products of valepotriates from Valeriana jatamansi and their cytotoxic activity
Three new decomposition products of valepotriates, valtrals A–C (1–3), and two known products, baldrinal and homobaldrinal, are formed during the isolation procedure of the ethanol extract of the…
Another Look at Pyrroloiminoquinone Alkaloids—Perspectives on Their Therapeutic Potential from Known Structures and Semisynthetic Analogues
High-accuracy electrospray ionization mass spectrometry (HAESI-MS) m/z ions produced through MS2 runs were obtained and interpreted to provide a rapid way for dereplicating isomers containing a pyrrolo[4,3,2-de]quinoline core.
Cyclopenicillone, a unique cyclopentenone from the cultures of Penicillium decumbens.
Cyclopenicillone demonstrated a dose-dependent (10-100 μM) inhibition against LPS-induced NO production in RAW264.7 macrophages.
Revision of the Structures of 1,5-Dihydroxy-3,8-epoxyvalechlorine, Volvaltrate B, and Valeriotetrate C from Valeriana jatamansi and V. officinalis.
The structures of 1,5-dihydroxy-3,8-epoxyvalechlorine (1a) and volvaltrate B (6a), two new chlorinated iridoids isolated from Valeriana jatamansi and V. officinalis, respectively, were originally…
Valeriana jatamansi constituent IVHD-valtrate as a novel therapeutic agent to human ovarian cancer: in vitro and in vivo activities and mechanisms.
The preclinical results indicated IVHD-valtrate is a potential therapeutic agent for ovarian cancer, providing a basis for development of the compound as a novel chemotherapeutic agent.
Minor valepotriates from Valeriana jatamansi and their cytotoxicity against metastatic prostate cancer cells.
Ten new valepotriates, jatamanvaltrates P-Y (1-10) and a known one, nardostachin (11), have been isolated from the whole plants of Valeriana jatamansi. The structures of the new compounds were…
Three minor valepotriate isomers from Valeriana jatamansi and their cytotoxicity
- Sheng Lin, P. Fu, Tao Chen, Ji Ye, Xianwen Yang, Wei-Dong Zhang
- Chemistry, BiologyJournal of Asian natural products research
- 2 January 2017
Three new minor valepotriate isomers, jatamanvaltrates Z1, Z2, and Z3, have been isolated from the whole plants of Valeriana jatamansi by extensive spectroscopic analysis, especially 2D NMR and ESI-MS/MSn.