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A total of 752 odorant receptor (Or) genes, including pseudogenes, were identified in 11 Drosophila species and named after their orthologs in Drosophila melanogaster. The 813 Or genes, including 61 from D. melanogaster, were classified into 59 orthologous groups that are well supported by gene phylogeny. By reconciling with the gene family phylogeny, we(More)
Given a movie comment, does it contain a spoiler? A spoiler is a comment that, when disclosed, would ruin a surprise or reveal an important plot detail. We study automatic methods to detect comments and reviews that contain spoilers and apply them to reviews from the IMDB (Inter-net Movie Database) website. We develop topic models, based on Latent Dirichlet(More)
Modeling the movement of information within social media outlets, like Twitter, is key to understanding to how ideas spread but quantifying such movement runs into several difficulties. Two specific areas that elude a clear characterization are (i) the intrinsic random nature of individuals to potentially adopt and subsequently broadcast a Twitter topic,(More)
Quetiapine (Que), a commonly used atypical antipsychotic drug (APD), can prevent myelin from breakdown without immune attack. Multiple sclerosis (MS), an autoimmune reactive inflammation demyelinating disease, is triggered by activated myelin-specific T lymphocytes (T cells). In this study, we investigated the potential efficacy of Que as an(More)
BACKGROUND Homeobox genes murine Rhox5 and human RHOXF1 are expressed in early embryonic stages and then mostly restricted to germline tissues in normal adult, yet they are aberrantly expressed in cancer cells in vitro and in vivo . Here we study the epigenetic regulation and potential functions of Rhox5 gene. FINDINGS In Rhox5-silenced or extremely low(More)
VGGNets have turned out to be effective for object recognition in still images. However, it is unable to yield good performance by directly adapting the VGGNet models trained on the ImageNet dataset for scene recognition. This report describes our implementation of training the VGGNets on the large-scale Places205 dataset. Specifically , we train three(More)
We introduce PASTA, a new multiple sequence alignment algorithm. PASTA uses a new technique to produce an alignment given a guide tree that enables it to be both highly scalable and very accurate. We present a study on biological and simulated data with up to 200,000 sequences, showing that PASTA produces highly accurate alignments, improving on the(More)
Evolutionary and systems biology increasingly rely on the construction of large phylogenetic trees which represent the relationships between species of interest. As the number and size of such trees increases, so does the need for efficient data storage and query capabilities. Although much attention has been focused on XML as a tree data model,(More)
We have armed a tumor-selective oncolytic vaccinia virus (vvDD) with the chemokine (CK) CXCL11, in order to enhance its ability to attract CXCR3 C antitumor CTLs and possibly NK cells to the tumor microenvironment (TME) and improve its therapeutic efficacy. As expected, vvDD-CXCL11 attracted high numbers of tumor-specific T cells to the TME in a murine AB12(More)