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A total of 752 odorant receptor (Or) genes, including pseudogenes, were identified in 11 Drosophila species and named after their orthologs in Drosophila melanogaster. The 813 Or genes, including 61 from D. melanogaster, were classified into 59 orthologous groups that are well supported by gene phylogeny. By reconciling with the gene family phylogeny, we(More)
VGGNets have turned out to be effective for object recognition in still images. However, it is unable to yield good performance by directly adapting the VGGNet models trained on the ImageNet dataset for scene recognition. This report describes our implementation of training the VGGNets on the large-scale Places205 dataset. Specifically , we train three(More)
Modeling the movement of information within social media outlets, like Twitter, is key to understanding to how ideas spread but quantifying such movement runs into several difficulties. Two specific areas that elude a clear characterization are (i) the intrinsic random nature of individuals to potentially adopt and subsequently broadcast a Twitter topic,(More)
Given a movie comment, does it contain a spoiler? A spoiler is a comment that, when disclosed, would ruin a surprise or reveal an important plot detail. We study automatic methods to detect comments and reviews that contain spoilers and apply them to reviews from the IMDB (Inter-net Movie Database) website. We develop topic models, based on Latent Dirichlet(More)
Quetiapine (Que), a commonly used atypical antipsychotic drug (APD), can prevent myelin from breakdown without immune attack. Multiple sclerosis (MS), an autoimmune reactive inflammation demyelinating disease, is triggered by activated myelin-specific T lymphocytes (T cells). In this study, we investigated the potential efficacy of Que as an(More)
This work presented a new analytical methodology based on hydrophilic interaction ultra-performance liquid chromatography coupled with triple-quadrupole tandem mass spectrometry in multiple-reaction monitoring mode for analysis of 24 underivatized free amino acids (FAAs) in functional foods. The proposed method was first reported and validated by assessing(More)
We introduce PASTA, a new multiple sequence alignment algorithm. PASTA uses a new technique to produce an alignment given a guide tree that enables it to be both highly scalable and very accurate. We present a study on biological and simulated data with up to 200,000 sequences, showing that PASTA produces highly accurate alignments, improving on the(More)
Evolutionary and systems biology increasingly rely on the construction of large phylogenetic trees which represent the relationships between species of interest. As the number and size of such trees increases, so does the need for efficient data storage and query capabilities. Although much attention has been focused on XML as a tree data model,(More)
Given a drug under development, what are other drugs or biochemical compounds that it might interact with? Early answers to this question, by mining the literature, are valuable for pharmaceutical companies, both monetarily and in avoiding public relations nightmares. Inferring drug-drug interactions is also important in designing combination therapies for(More)
The inhibitory receptor programmed death-1 (PD-1) has the capacity to maintain peripheral tolerance and limit immunopathological damage; however, its precise role in fulminant viral hepatitis (FH) has yet to be described. Here, we investigated the functional mechanisms of PD-1 as related to FH pathogenesis induced by the murine hepatitis virus strain-3(More)