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[Regulatory effects of micronutrient complex on the expression of Th1 and Th2 cytokines in diabetic C57BL mice].
- Ying Chang, S. Piao, Shen Gao, De-ming Zheng
- Medicine, BiologyWei sheng yan jiu = Journal of hygiene research
MC may prevent from the onset and development of IDDM by down- Regulating Th1 cytokines genes expression and up-regulating Th2 cytokine genes expression of ID DM mice.
Reversal of MDR1 gene-dependent multidrug resistance using short hairpin RNA expression vectors.
BACKGROUND RNA interference using short hairpin RNA (shRNA) can mediate sequence-specific inhibition of gene expression in mammalian cells. A vector-based approach for synthesizing shRNA has been…
Study on the bone marrow mesenchymal stem cells induced drug resistance in the U937 cells and its mechanism.
MSCs play a role in modulating the proliferation of U 937 cells and response of U937 cells to DNR, and Bcl-XL apoptosis-inhibiting gene may be most important in determining the sensitivity of leukemic cells to treatment.
[Influence of human mesenchymal stem cells on cell proliferation and chemo-sensitivity of K562 cells].
- Yu-mei Lin, Li-Mei Bu, Shao-juan Yang, Shen Gao, Gui-zhen Zhang
- BiologyZhongguo shi yan xue ye xue za zhi
- 1 April 2006
By co-culture of cell-cell contact with MSC, growth suppression and induction of chemo-resistance of K562 cells take place, however, the mechanism seems not relevant with MDR1.
Protective effects of combined micronutrients on islet beta-cells of streptozotocin-induced diabetic mice.
- Ying Chang, Gui-zhen Zhang, S. Ying
- Medicine, BiologyInternational journal for vitamin and nutrition…
- 1 March 2009
There is a tendency for the incidence of diabetes in a population to increase with an improvement in living standards. This would imply the involvement of nutritional factors in the development of…
Study on pancreatic islet cell protection of selenium and vitamn E
The dietary supplementation of both Se 0.2mg/kg and VE 500 mg/kg brought about an obvious increase of insulin contents both in serum and islets, decrease of the fructosamine content in serumand increase of GSH-Px and SOD activities in pancreas of DM rats.
[Study of apoptosis gene expression in U937 cells induced by adhesion culture with mesenchymal stem cell].
- Yu-mei Lin, Gui-zhen Zhang, Zhen-xia Lu, Zong-xiang Leng, Li-sha Bu, Shen Gao
- Biology, MedicineZhonghua xue ye xue za zhi = Zhonghua xueyexue…
- 1 April 2006
Adhesion culture with MSCs can lead to growth suppression and decrease natural apoptosis of U937 cells, but Bcl-XL may be of the most importance.
[Reversal of mdrl gene-dependent multidrug resistance in multidrug resistance human leukemia cell line K562/ADM using short hairpin RNA expression vectors].
- Hui-zhu Gan, Gui-zhen Zhang, De-ming Zheng
- BiologyZhonghua xue ye xue za zhi = Zhonghua xueyexue…
- 1 June 2007
ShRNA expression vectors can effectively reverse MDR, and restore the sensitivity of drug-resistance K562/ADM cells to conventional chemotherapeutic agents.
Impact of human resistin on glucose uptake in adipocytes and its mechanism
The results suggested that human resistin impaired glucose uptake in adipoeytes via stimulating proliferation of preadipocytes and suppressing adipocyte differentiation, and metformin reversed the inhibition imposed by resistin on adipogenesis.