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Diabetes promotes an inflammatory macrophage phenotype and atherosclerosis through acyl-CoA synthetase 1.

• Jenny E Kanter, Farah Kramer, +16 authors Karin E Bornfeldt
• Proceedings of the National Academy of Sciences…
• 2012

The mechanisms that promote an inflammatory environment and accelerated atherosclerosis in diabetes are poorly understood. We show that macrophages isolated from two different mouse models of type 1… (More)

Long-chain acyl-CoA synthetase 4 modulates prostaglandin E₂ release from human arterial smooth muscle cells.

• Deidre L. Golej, Bardia Askari, +4 authors Karin E Bornfeldt
• Journal of lipid research
• 2011

Long-chain acyl-CoA synthetases (ACSLs) catalyze the thioesterification of long-chain FAs into their acyl-CoA derivatives. Purified ACSL4 is an arachidonic acid (20:4)-preferring ACSL isoform, and… (More)

S100A9 differentially modifies phenotypic states of neutrophils, macrophages, and dendritic cells: implications for atherosclerosis and adipose tissue inflammation.

• Michelle M. Averill, Shelley Barnhart, +7 authors Karin E Bornfeldt
• Circulation
• 2011

BACKGROUND S100A9 is constitutively expressed in neutrophils, dendritic cells, and monocytes; is associated with acute and chronic inflammatory conditions; and is implicated in obesity and… (More)

Testing the role of myeloid cell glucose flux in inflammation and atherosclerosis.

• Tomohiro Nishizawa, Jenny E Kanter, +12 authors Karin E Bornfeldt
• Cell reports
• 2014

Inflammatory activation of myeloid cells is accompanied by increased glycolysis, which is required for the surge in cytokine production. Although in vitro studies suggest that increased macrophage… (More)

Type 1 diabetes promotes disruption of advanced atherosclerotic lesions in LDL receptor-deficient mice.

• Fredrik Johansson, Farah Kramer, +9 authors Karin E Bornfeldt
• Proceedings of the National Academy of Sciences…
• 2008

Cardiovascular disease, largely because of disruption of atherosclerotic lesions, accounts for the majority of deaths in people with type 1 diabetes. Recent mouse models have provided insights into… (More)

Aggressive very low-density lipoprotein (VLDL) and LDL lowering by gene transfer of the VLDL receptor combined with a low-fat diet regimen induces regression and reduces macrophage content in…

• Erin D MacDougall, Farah Kramer, +9 authors Karin E Bornfeldt
• The American journal of pathology
• 2006

Very low-density lipoprotein (VLDL) and LDL plasma levels are associated with cardiovascular mortality. Whereas VLDL/LDL lowering causes regression of early atherosclerotic lesions, less is known… (More)

Endothelial acyl-CoA synthetase 1 is not required for inflammatory and apoptotic effects of a saturated fatty acid-rich environment.

• Xin Li, Oscar Sandoval Gonzalez, +11 authors Karin E Bornfeldt
• Arteriosclerosis, thrombosis, and vascular…
• 2013

OBJECTIVE Saturated fatty acids, such as palmitic and stearic acid, cause detrimental effects in endothelial cells and have been suggested to contribute to macrophage accumulation in adipose tissue… (More)

Effects of High Fat Feeding and Diabetes on Regression of Atherosclerosis Induced by Low-Density Lipoprotein Receptor Gene Therapy in LDL Receptor-Deficient Mice

• Florian K. Willecke, Chujun Yuan, +7 authors Alberico L. Catapano
• PloS one
• 2015

We tested whether a high fat diet (HFD) containing the inflammatory dietary fatty acid palmitate or insulin deficient diabetes altered the remodeling of atherosclerotic plaques in LDL receptor… (More)

Novel Reversible Model of Atherosclerosis and Regression Using Oligonucleotide Regulation of the LDL Receptor.

• Debapriya Basu, Yunying Hu, +11 authors Ira J Goldberg
• Circulation research
• 2018

RATIONALE Animal models have been used to explore factors that regulate atherosclerosis. More recently, they have been used to study the factors that promote loss of macrophages and reduction in… (More)

Myeloid Cell Prostaglandin E2 Receptor EP4 Modulates Cytokine Production but Not Atherogenesis in a Mouse Model of Type 1 Diabetes

• Sara N. Vallerie, Farah Kramer, +4 authors Karin E Bornfeldt
• PloS one
• 2016

Type 1 diabetes mellitus (T1DM) is associated with cardiovascular complications induced by atherosclerosis. Prostaglandin E2 (PGE2) is often raised in states of inflammation, including diabetes, and… (More)

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