Sheldon Feldman

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Breast cancer in African-American (AA) women occurs at an earlier age than in European-American (EA) women and is more likely to have aggressive features associated with poorer prognosis, such as high-grade and negative estrogen receptor (ER) status. The mechanisms underlying these differences are unknown. To address this, we conducted a case-control study(More)
BACKGROUND The presence of tumor cells at the margins of breast lumpectomy specimens is associated with an increased risk of ipsilateral tumor recurrence. Twenty to 30 % of patients undergoing breast-conserving surgery require second procedures to achieve negative margins. This study evaluated the adjunctive use of the MarginProbe device (Dune Medical(More)
The American Society of Breast Surgeons (ASBrS) endorses the American Board of Internal Medicine's Choosing Wisely campaign statement: ''Don't routinely perform a double mastectomy in patients who have a single breast with cancer.'' 1 However, women with a newly diagnosed unilateral breast cancer are increasingly opting for bilateral mastectomy. This has(More)
The American Society of Breast Surgeons (ASBrS) encourages an evidence-based and patient value focused approach to contralateral prophylactic mastectomy (CPM). The ASBrS convened a panel of experts to develop a consensus statement on CPM. 1 The majority of women will obtain no oncologic benefit from CPM, and therefore CPM should be discouraged in(More)
Breast cancer is the second leading cause of death in women in the United States due to cancer. Early detection of breast cancerous regions will aid the diagnosis, staging, and treatment of breast cancer. Optical coherence tomography (OCT), a non-invasive imaging modality with high resolution, has been widely used to visualize various tissue types within(More)
BACKGROUND Multiple recent reports have documented significant variability of reoperation rates after initial lumpectomy for breast cancer. To address this issue, a multidisciplinary consensus conference was convened during the American Society of Breast Surgeons 2015 annual meeting. METHODS The conference mission statement was to "reduce the national(More)
Copyright © 2013 Sheldon Marc Feldman. is is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Signi�cant progress has been made in the diagnosis and treatment of breast cancer during the past 30(More)
Background. The MammaPrint (MP) diagnostic assay stratifies breast cancer patients into high- and low-risk groups using mRNA analysis of a 70-gene profile. The assay is validated for assessment of patients with estrogen receptor positive or negative tumors less than 5 cm with 3 or fewer malignant lymph nodes. TargetPrint (TP) is an assay for assessing(More)
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