Sheilah Hoelscher

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Using a clonal strain of cultured Leydig tumor cells (designated MA-10), we have compared the internalization and degradation of human CG (hCG) and deglycosylated hCG. Deglycosylated hCG is a derivative of hCG which retains the ability to bind to the LH/CG receptor, but is unable to activate adenylyl cyclase and thus stimulate cAMP production. A comparison(More)
Although hCG and mouse epidermal growth factor (mEGF) activate different signaling systems in a clonal strain of murine Leydig tumor cells (designated MA-10), both compounds ultimately elicit several common effects, such as increased steroidogenesis, decreased transcription of the LH/CG receptor gene, and attenuation of adenylyl cyclase. Based on this(More)
Although hCG and mouse epidermal growth factor (mEGF) activate different signaling systems in a clonal strain of murine Leydig tumor cells (designated MA-10), both compounds ultimately elicit several common effects such as increased steroidogenesis, decreased transcription of the LH receptor gene and attenuation of adenylyl cyclase. A 21-kilodalton protein(More)
Although hCG and mouse epidermal growth factor activate different signaling systems in a clonal strain of Leydig tumor cells (designated MA-10), both compounds are capable of increasing steroidogenesis, decreasing transcription of the LH/CG receptor gene, and attenuating adenylyl cyclase. We have recently identified a 21-kilodalton protein (p21) that is a(More)
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