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Aspirin has an established benefit in reducing the incidence of coronary events and vein graft occlusion. We have now assessed the risk of pre-operative aspirin in a prospective, randomised, double-blind clinical trial in 100 patients scheduled for elective coronary artery surgery. Any prescribed aspirin and non-steroidal anti-inflammatory drugs were(More)
We present two instructive cases of imidazoline poisoning in young children. Imidazoline decongestants, readily available in numerous non-prescription preparations, can rapidly produce toxicity from oral ingestion and topical application. Signs and symptoms depend on whether peripheral or central alpha 2-adrenergic receptor stimulation predominates. Timely(More)
The committee's first report, published in Circulation for June 1953, recommended a terminology and certain conventions for recording ballistocardiograms of the type then in use. However, it soon became apparent that the committee's work was far from complete. Increasing knowledge of ballistic theory soon began to throw light on the relations of records(More)
Noonan's syndrome is characterised by a dysmorphic facies, congenital heart disease, and short stature, and is inherited as an autosomal dominant trait. Because abnormal bleeding has also been reported, we investigated a group of patients for coagulation-factor deficits. Of the 72 individuals studied (37 male, 35 female, mean age 11.4 years), 47 (65%) had a(More)
Expanded polytetrafluoroethylene (PTFE) (Gore-Tex) grafts were used in 16 patients with ischemic heart disease undergoing aorta-coronary bypass graft operations. PTFE was used only when insufficient suitable vein was available. A total of 27 grafts were inserted in 16 patients. Eighteen grafts (in 11 patients) were studied in the early (3 months)(More)
The present recommendation is that aprotinin should be started before cardiac surgery, but as bleeding is only a problem in a minority, most patients are treated unnecessarily. In a prospective, randomised, double-blind trial we have studied the use of aprotinin, given only to the minority of patients who bled significantly post-operatively and who had not(More)
BACKGROUND Factor VII polymorphisms have been suggested in some studies to show an association with some aspects of coronary disease, and there is a known association between FVII levels and polymorphic variants in the gene. The aim of the study was to assess whether Factor VII polymorphism R353Q is associated with the extent of coronary artery disease in(More)