Sheila T. Angeles-Han

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Purpose To demonstrate the clinical features and predisposing factors of pulmonary thrombotic events in children with rheumatic diseases. Results Thrombotic events have been associated with antipho-spholipid antibodies in autoimmune diseases, including systemic lupus erythematosus (SLE). However, pulmonary thromboembolism (PTE) from deep vein thromboses(More)
OBJECTIVE There is wide variation in therapeutic approaches to systemic juvenile idiopathic arthritis (JIA) among North American rheumatologists. Understanding the comparative effectiveness of the diverse therapeutic options available for treatment of systemic JIA can result in better health outcomes. The Childhood Arthritis and Rheumatology Research(More)
Purpose Rheumatoid arthritis (RA) is an inflammatory arthritis with a peak onset age of ~50. Children with rheumatoid factor and/or anti-citrullinated peptide antibody positive juvenile idiopathic arthritis resemble adults with RA, and represent the childhood onset of RA (CORA). Variants of the genes encoding human leukocyte antigens (HLA) and several other(More)
BACKGROUND The association between rheumatoid arthritis (RA) and periodontitis is well established. Some children with juvenile idiopathic arthritis (JIA) phenotypically resemble adults with RA, characterized by the presence of anti-cyclic citrullinated peptide (CCP) antibodies. We sought to investigate an association between CCP-positive JIA and symptoms(More)
BACKGROUND Although more than 100 non-HLA variants have been tested for associations with juvenile idiopathic arthritis (JIA) in candidate gene studies, only a few have been replicated. We sought to replicate reported associations of single nucleotide polymorphisms (SNPs) in the PTPN22, TNFA and MIF genes in a well-characterized cohort of children with JIA.(More)
Juvenile idiopathic arthritis (JIA) is a chronic rheumatic disease associated with pain, stiffness and increased psychosocial burden. The purpose of this study was to investigate through an ABAB single-case design the impact of a yoga intervention on pain and morning stiffness in adolescent females with JIA. A secondary aim was to assess the impact of this(More)
BACKGROUND There is not yet a commonly accepted, standardized approach in the treatment of juvenile idiopathic uveitis when initial steroid therapy is insufficient. We sought to assess current practice patterns within a large cohort of children with juvenile uveitis. METHODS This is a cross-sectional cohort study of patients with uveitis enrolled in the(More)
BACKGROUND Clinically distinct autoimmune phenotypes share genetic susceptibility factors. We investigated the prevalence of familial autoimmunity among subjects with juvenile idiopathic arthritis (JIA), childhood systemic lupus erythematosus (cSLE) and juvenile dermatomyositis (JDM) in the CARRA Registry, the largest multicenter observational Registry for(More)
PURPOSE Juvenile idiopathic arthritis (JIA)-associated uveitis can lead to ocular complications and vision loss. Alleles HLA-DRB1*08, *11, and *13 are risk alleles for JIA, whereas HLA-DRB1*11 and *13 alleles increase uveitis susceptibility. We examined the association of common HLA-DRB1 alleles in children with JIA alone and JIA-associated uveitis. (More)
BACKGROUND Juvenile idiopathic arthritis-associated uveitis (JIA-U) can lead to poor visual outcomes and impact a child's quality of life (QOL) and function. Our aim is to identify risk markers of JIA-U and examine differences in the QOL of children with JIA and JIA-U. METHODS Rheumatology and ophthalmology record reviews and questionnaires were completed(More)