Sheila L. Chan

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Motor training can induce profound physiological plasticity within primary motor cortex, including changes in corticospinal output and motor map topography. Using transcranial magnetic stimulation, we show that training-dependent increases in the amplitude of motor-evoked potentials and motor map reorganization are reduced in healthy subjects with a(More)
OBJECTIVE The aims of this study were to evaluate a multiyear experience with subdural evacuating port system (SEPS) placement for chronic subdural hematoma (cSDH) in the intensive care unit at a tertiary neurosurgical center and to compare SEPS placement with bur hole evacuation in the operating room. METHODS All cases of cSDH evacuation were captured over(More)
BACKGROUND AND PURPOSE Outpatient statin use reduces the risk of recurrent ischemic stroke among patients with stroke of atherothrombotic cause. It is not known whether statins have similar effects in ischemic stroke caused by atrial fibrillation (AFib). METHODS We studied outpatient statin adherence, measured by percentage of days covered, and the risk(More)
OBJECTIVE External ventricular drains (EVDs) historically have a high rate of infection, and EVD infections are a cause of significant morbidity and mortality. We have shown previously that a simple infection control protocol reduced the rate of EVD infections during a 3-year period, and the present study examines whether infection rates were durably(More)
BACKGROUND Statin administration early in ischemic stroke may influence outcomes. Our aim was to determine the clinical impact of increasing statin administration early in ischemic stroke hospitalization. METHODS AND RESULTS This is a retrospective analysis of a multicenter electronic medical record (EMR) intervention to increase early statin(More)
BACKGROUND AND PURPOSE The Totaled Health Risks in Vascular Events (THRIVE) score is a previously validated ischemic stroke outcome prediction tool. Although simplified scoring systems like the THRIVE score facilitate ease-of-use, when computers or devices are available at the point of care, a more accurate and patient-specific estimation of outcome(More)
Intracranial hemorrhage in patients with mechanical heart valves carries a risk of thrombosis and of rehemorrhage. Because interruption of anticoagulation with a mechanical heart valve may lead to thrombotic events, cardiologist recommendations generally lean toward minimizing the time off anticoagulation, although valve guidelines do not specifically(More)
BACKGROUND Hematoma expansion confers excess mortality in intracerebral haemorrhage, and is potentially preventable if at-risk patients can be identified. Contrast extravasation on initial computed tomographic angiography strongly predicts hematoma expansion but is not very sensitive, and most centers have not yet integrated computed tomographic angiography(More)
BACKGROUND Patients admitted to an intensive care unit (ICU) with a primary neurologic disorder often receive multiple radiation-based diagnostic studies of the head and neck. Although radiation exposure puts them at risk of intracranial and neck tumors, the amount of radiation received is largely unknown. METHODS We sought to accurately collect(More)
Speckle noise and artifacts in echocardiogram may cause edges to manifest themselves in different manners. As a result, edges in echocardiogram are identified with ambiguous definitions and they pose challenges for conventional gradient approximations that typically characterize an edge as an abrupt change in gray-level. Therefore, an approach using fuzzy(More)
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