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Identification of human brain tumour initiating cells
The development of a xenograft assay that identified human brain tumour initiating cells that initiate tumours in vivo gives strong support for the CSC hypothesis as the basis for many solid tumours, and establishes a previously unidentified cellular target for more effective cancer therapies. Expand
Identification of a cancer stem cell in human brain tumors.
The identification and purification of a cancer stem cell from human brain tumors of different phenotypes that possesses a marked capacity for proliferation, self-renewal, and differentiation is reported. Expand
Cancer stem cells in nervous system tumors
The identification of a brain tumor stem cells (BTSC) provides a powerful tool to investigate the tumorigenic process in the central nervous system and to develop therapies targeted to the BTSC. Expand
Endovascular Thrombectomy for Acute Ischemic Stroke: A Meta-analysis.
Among patients with acute ischemic stroke, endovascular therapy with mechanical thrombectomy vs standard medical care with tPA was associated with improved functional outcomes and higher rates of angiographic revascularization, but no significant difference in symptomatic intracranial hemorrhage or all-cause mortality at 90 days. Expand
EMT: Mechanisms and therapeutic implications
- Mohini Singh, Nicolas Yelle, C. Venugopal, Sheila K Singh
- Biology, Medicine
- Pharmacology & therapeutics
- 20 August 2017
The sequence of events and defining mechanisms that take place during EMT are described, and how these interactions drive cancer cell progression into metastasis are described. Expand
Investigating the Link between Molecular Subtypes of Glioblastoma, Epithelial-Mesenchymal Transition, and CD133 Cell Surface Protein
- Hadi Zarkoob, J. Taube, Sheila K Singh, Sendurai A Mani, M. Kohandel
- Biology, Medicine
- PloS one
- 29 May 2013
A newly identified signature for epithelial-to-mesenchymal transition in human mammary epithelial cells is used, and it is demonstrated that genes in this signature have significant overlap with genes differentially expressed in all known GBM subtypes. Expand
Childhood Cerebellar Tumors Mirror Conserved Fetal Transcriptional Programs
Single-cell transcriptomics of human childhood cerebellar tumors demonstrates that many bulk tumors contain a mixed population of cells with divergent differentiation, and provides a proximate explanation for the peak incidence of cerebellary tumors in early childhood. Expand
Personalizing the treatment of pediatric medulloblastoma: Polo-like kinase 1 as a molecular target in high-risk children.
It is concluded that patients with medulloblastoma expressing high levels of PLK1 are at elevated risk and screened a library of 129 compounds in clinical trials using a model of pediatric medullOBlastoma and determined thatPLK1 inhibitors were the most promising class of agents against the growth of medulloplastoma. Expand
YB-1 bridges neural stem cells and brain tumor-initiating cells via its roles in differentiation and cell growth.
It is shown that YB-1 was highly expressed in the subventricular zone of mouse fetal brain tissues but not in terminally differentiated primary astrocytes, and correlatively expresses with NSC markers where it functions to promote cell growth and inhibit differentiation. Expand
Biopsy versus partial versus gross total resection in older patients with high-grade glioma: a systematic review and meta-analysis.
An upward improvement in survival time, functional recovery, and tumor recurrence rate associated with increasing extents of safe resection is suggested. Expand