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Oral epithelial tumour tissue, and cultured cervical epithelial carcinoma cells have been studied using synchrotron infrared microspectroscopy. Mid infrared absorption spectra collected at cellular spatial resolution from within oral tumours were found to be sufficiently distinct, when analysed by principal component analysis, to distinguish between three(More)
One-hundred patients undergoing radial forearm flap reconstruction in the head and neck over a 2-year period were followed prospectively to assess complications and morbidity associated with the radial flap donor site. Eighty-six patients were available follow-up at 3 months and 74 at 1 year (49 fasciocutaneous, 25 composite). Partial loss of the donor-site(More)
Clinical function and health-related quality of life (HRQoL) are both important outcome parameters following surgery for oral and oropharyngeal cancer. The aim of this project was to explore the relationship between an 11-point clinical examination and HRQoL. Of 132 consecutive patients undergoing surgery for previously untreated disease between January(More)
The histological changes following removal of 2 cm discs of buccal mucosa by CO2 laser and conventional surgery were studied over a period of 42 days. The laser wound differed from the conventional wound: there was minimal damage to the adjacent tissue; initially a coagulum of denatured protein formed on the surface; the inflammatory reaction was less;(More)
The purpose of this study was to examine the impact of surgical, radiotherapeutic and combination treatment on quality of life, in patients diagnosed with cancer of the oral cavity and oropharynx. During the acute stage of treatment, quality of life was longitudinally evaluated. Quality of life was assessed at frequent time intervals (diagnosis, two weeks,(More)
PURPOSE The EORTC QLQ-H&N35 (H&N35) is widely used to measure quality of life in head and neck cancer patients. The aims of this study were to obtain insight into a) the languages in which the H&N35 has been used and the psychometric properties in those languages, b) the study designs, and c) its acceptance by patients and investigators. METHODS A(More)
The carbon dioxide laser has become more widely available in recent years and is now employed in many branches of surgery. It is important to understand its biological effect on oral tissues so that the likely response in patients can be predicted. However, little information has been published on the healing mechanism of oral wounds. A study of the healing(More)
Secondary use of patient databases is essential in healthcare if clinical trials are to progress efficiently to planned time and target and imperative if the planned UK expansion of research and development (R&D) at point of care is to be achieved. Integration of effective databases primarily designed to facilitate patient care with R&D requirements is(More)