Sheetanshu Grover

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The mechanism of pain in dentine hypersensitivity is poorly understood but proposed to result from the activation of dental sensory neurons in response to dentinal fluid movements. Odontoblasts have been suggested to contribute to thermal and mechanosensation in the tooth via expression of transient receptor potential (TRP) channels. However, a mechanism by(More)
BACKGROUND AND PURPOSE The Ca(2+) -permeable cation channel TRPV4 is activated by mechanical disturbance of the cell membrane and is implicated in mechanical hyperalgesia. Nerve growth factor (NGF) is increased during inflammation and causes mechanical hyperalgesia. 4α-phorbol 12,13-didecanoate (4αPDD) has been described as a selective TRPV4 agonist. We(More)
Helicoverpa armigera is the most devastating pest of important crops causing heavy yield losses. The larval midgut harbours proteases and their inhibition starves insects to death or may disrupt their normal metabolism. So there is need to characterize gut protease and its potential inhibitors. A serine protease (trypsin like) from H. armigera gut was(More)
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