Sheena-Margaret Cruickshank

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AIM To determine if primary murine colonic epithelial cells (CEC) respond to commensal bacteria and discriminate between different types of bacteria. METHODS A novel CEC: bacteria co-culture system was used to compare the ability of the colonic commensal bacteria, Bacteroides ovatus, E. coli (SLF) and Lactobacillus rhamnosus (LGG) to modulate production(More)
1. The gastropod mollusc Lymnaea stagnalis (L.) is an ideal model system for studies on anaesthesia. It is reversibly anaesthetized by the general anaesthetics halothane, enflurane and isoflurane. 2. Criteria for "anaesthesia" in Lymnaea were established. The reflex used in ED50 trials was the whole animal withdrawal reflex. 3. ED50 values for halothane,(More)
1. A delivery system for the application of general anaesthetics or other gaseous and volatile agents to superfused, isolated preparations is described in detail. 2. This system delivers known concentrations of anaesthetic and controls for evaporation and absorption of volatile agents, whilst allowing intracellular electrophysiological recordings to be made(More)
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