Sheena D. Singh

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Candida albicans is the leading fungal pathogen of humans, causing life-threatening disease in immunocompromised individuals. Treatment of candidiasis is hampered by the limited number of antifungal drugs whose efficacy is compromised by host toxicity, fungistatic activity, and the emergence of drug resistance. We previously established that the molecular(More)
committed toward the neuronal lineage and are very similar to the fetal neural stem cells. In our so far published papers, we have successfully attempted to establish stem cell-based in vitro model systems for the study of the various aspects of DNT and have proven that human umbilical cord blood-derived stem cells (hUCBSCs) when differentiated into neurons(More)
Heat stress causes an array of physiological, biochemical and morphological changes in plants, affecting growth and yield. Here, we report cloning of HSP90 gene of 2,323 bp from C-306 cultivar of wheat having ORF from 62 to 2,164 bp encoded for 700 amino acids. Quantitative real time expression analysis of HSP90 gene in C-306 showed 1.5, 1.2, 2.5 fold (in(More)
Stem cell biology has played a pivotal role in the field of disease modeling, regenerative medicine, and tissue engineering. The scope of stem cell research has been further extended to address the issues associated with toxicity and biosafety. However, its role in the field of neurotoxicity (NT) and the emerging field of developmental neurotoxicity (DNT)(More)
The profound significance of autophagy as a cell survival mechanism under conditions of metabolic stress is a well-proven fact. Nearly a decade-long research in this area has led scientists to unearth various roles played by autophagy other than just being an auto cell death mechanism. It is implicated as a vital cell survival pathway for clearance of all(More)
The use of Jatropha curcas L. (Jatropha) as biofuel is currently increasing in tropical and sub-tropical regions. Jatropha species are well known for synthesizing various toxicants. However, the effects of Jatropha plantation on soil microbiota have barely been investigated. Hence, in current experiment, we had investigated the effects of Jatropha(More)
Mustard (Brassica juncea) var. Pusa Jaikisan was grown in a pot experiment in soil supplemented with different concentrations of nickel and chromium (50 and 100 mg kg−1 soil), lead (100 and 200 mg kg−1 soil), cadmium (5 and 10 mg kg−1 soil) and mercury (25 and 50 mg kg−1 soil) as a leafy vegetable. The study revealed that as the contamination level(More)
Gram-negative plant pathogenic bacteria regulate specific gene expression in a population density-dependent manner by sensing level of Acyl-Homoserine Lactone (HSL) molecules which they produce and liberate to the environment, called Quorum Sensing (QS). The production of virulence factors (extracellular enzyme viz. cellulase, pectinase, etc.) in(More)
Four field experiments, two experiments each during winter season of 2012–2013 and 2013–2014, were conducted to evaluate effect of sowing time and four wheat cultivars on population of wheat aphids. Wheat crop was found infested with Rhopalosiphum padi and Sitobion avenae in various proportions in different experiments. During vegetative crop phase,(More)
Increasing temperature is likely to affect productivity of wheat and chickpea crop. A field experiment was conducted for two consecutive years with wheat and chickpea crop raised inside the temperature gradient tunnel (TGT). Results showed that high temperature reduced crop growth duration in both the crops. Days to 50 % flowering reduced by 4–5 days in(More)
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