Sheeba Joseph

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Photodynamic therapy (PDT) is an efficient inducer of apoptosis in many types of cells, except in cells deficient in one or more of the factors that mediate apoptosis. Recent reports have identified autophagy as a potential alternative cell death process following PDT. Here we investigated the occurrence of autophagy after PDT with the photosensitizer Pc 4(More)
The design of neural prostheses to restore standing balance, prevent foot drop, or provide active propulsion during ambulation requires detailed knowledge of the distal sciatic nerve anatomy. Three complete sciatic nerves and branches were dissected from the piriformis to each muscle entry point to characterize the branching patterns and diameters. Fascicle(More)
Following a short period of fasting, with free access to water, lipid droplet accumulation (LDA) occurs in many glandular organs as well as in the heart of several species. The present work describes the changes in the hearts of male and female rats of different ages (6, 12, 18 and 24 weeks) deprived of food for 1, 2 and 3 days. LDA was demonstrated by(More)
Photodynamic therapy (PDT) induces apoptosis in many cell types. Recent reports identified autophagy as an alternative cell-death process following PDT. Here we investigated the occurrence of autophagy after PDT with the photosensitizer Pc 4 in human cancer cells that are deficient in the pro-apoptotic factor Bax (human prostate cancer DU145) or the(More)
Results We examined virus in blood and CSF in eight subjects with advanced HIV disease and with neurocognitive involvement. All eight subjects had highly compartmentalized virus in comparing blood and CSF. In half of the subjects, the virus decayed rapidly in blood and CSF when therapy was initiated, and all env genes tested could infect cells only when(More)
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