She-Hung Chan

Publications31
h-index12
Citations335
Highly Influential Citations12
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Pre-assembly of STAT4 with the human IFN-alpha/beta receptor-2 subunit is mediated by the STAT4 N-domain.
The effects of antiepileptic drugs on the growth of glioblastoma cell lines
TLDR
The growth enhancement effects of ethosuximide, levetiracetam, and vigabatrin found in the study may indicate that these compounds should not be used for prophylaxis or short term treatment of epilepsy in glioblastoma.
Raised Proinflammatory Cytokine Production Within Cerebrospinal Fluid Precedes Fever Onset in Patients With Neurosurgery-Associated Bacterial Meningitis*
TLDR
It is suggested that raised cerebrospinal fluid tumor necrosis factor, interleukin-1&bgr;, and interleucin-8 in a temporal manner may indicate early bacterial meningitis development in neurosurgical patients, enabling earlier diagnostic certainty and improved patient outcomes.
Interleukin-1 system messenger ribonucleic acid and protein expression in human fallopian tube may be associated with ectopic pregnancy.
An integrated approach to elucidate signaling pathways of dioscin-induced apoptosis, energy metabolism and differentiation in acute myeloid leukemia
TLDR
The data suggest that dioscin exerts its antileukemic effect through the upregulation of both death ligands and death receptors and a crosstalk activation of mitochondrial apoptosis pathway with the collaboration of tBid and Bak formation.
Eutopic endometrial interleukin-18 system mRNA and protein expression at the level of endometrial-myometrial interface in adenomyosis patients.
A method to develop an in vitro osteoporosis model of porcine vertebrae: histological and biomechanical study.
TLDR
The data imply that the acid demineralizing process may be useful for producing a vertebra that has some biomechanical properties that are consistent with osteoporosis in humans.
Granulosa-lutein cell growth differentiation factor-9 (GDF-9) messenger RNA and protein expression in in vitro fertilization (IVF) cycles: relation to characteristics of ovulation induction and IVF.
Reevesioside A, a Cardenolide Glycoside, Induces Anticancer Activity against Human Hormone-Refractory Prostate Cancers through Suppression of c-myc Expression and Induction of G1 Arrest of the Cell…
TLDR
The data suggest that reevesioside A inhibits c-myc expression and down-regulates the expression of CDC25A, cyclin D1 and cyclin E, leading to a profound decrease of RB phosphorylation, which causes mitochondrial damage and an ultimate apoptosis in human hormone-refractory prostate cancer cells.
Terfenadine induces anti-proliferative and apoptotic activities in human hormone-refractory prostate cancer through histamine receptor-independent Mcl-1 cleavage and Bak up-regulation
TLDR
Terfenadine induced apoptotic signaling cascades against HRPCs in a sequential manner and caused the up-regulation and activation of Bak and the cleavage of Mcl-1, leading to the loss of ΔΨm andactivation of caspase cascades which further resulted in DNA damage response and cell apoptosis.
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