Shazhou Zou

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PURPOSE An objective, quantitative, and sensitive method to map retinal thickness is needed to diagnose more effectively the conditions causing alterations in thickness, such as macular edema and neuroretinal atrophy. METHODS An instrument, the retinal thickness analyzer, was developed into a rapid scanning instrument, capable of covering macular areas of(More)
OBJECTIVE The posterior pole ganglion cell bodies form a substantial fraction of the retinal thickness, prompting the authors to study the feasibility of detecting, by scanning retinal thickness analysis, retinal changes at the posterior pole due to glaucomatous damage. STUDY DESIGN Nonconsecutive case series. PARTICIPANTS One or both eyes of patients(More)
PURPOSE To increase the number of diabetic patients being screened for retinopathy, an instrument, the DigiScope, was specifically designed to operate in primary-care physicians' offices. The DigiScope is described and its automated functions are evaluated. METHODS The DigiScope consists of a semiautomated optical head to acquire fundus images, evaluate(More)
PURPOSE A new method, laser-targeted photoocclusion, was developed to occlude choroidal neovascularization while minimizing damage to the overlying retina. The ability to occlude normal choriocapillary layer in rats was evaluated as a first test of the feasibility of treating choroidal neovascularization with this method. METHOD A photosensitive agent,(More)
The biological mechanisms of nerve adaptation to distraction osteogenesis have not yet been elucidated. This study observed response of Schwann cells in the inferior alveolar nerve (IAN) following mandibular lengthening by electron microscopy and immunohistochemistry of S-100 protein, a specific marker of Schwann cells. Unilateral mandibular distraction(More)
PURPOSE The rat has been used to generate models of various eye diseases. However, methods to study the choriocapillaris noninvasively have been inadequate in this species. Laser-targeted angiography was applied to generate local, repetitive angiograms of the choriocapillaris in the rat and to assess the similarity between the choriocapillaris of the rat(More)
PURPOSE Laser-targeted angiography has unique advantages over conventional angiography of the fundus. Its efficacy in visualizing choroidal neovascular membranes was tested in a rat model and compared to that of fluorescein angiography. METHOD Laser-targeted angiography was performed in rats with choroidal neovascularization (CNV) by injecting(More)
This study assessed the changes in the condyle after mandibular lengthening with 2 different rates of distraction (1 mm/day and 2 mm/day). Unilateral mandibular distraction was performed in 8 young adult goats. The animals were sacrificed 8 weeks after the completion of distraction, and the temporomandibular joint (TMJ) specimens were harvested and(More)
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