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PURPOSE An objective, quantitative, and sensitive method to map retinal thickness is needed to diagnose more effectively the conditions causing alterations in thickness, such as macular edema and neuroretinal atrophy. METHODS An instrument, the retinal thickness analyzer, was developed into a rapid scanning instrument, capable of covering macular areas of(More)
PURPOSE To increase the number of diabetic patients being screened for retinopathy, an instrument, the DigiScope, was specifically designed to operate in primary-care physicians' offices. The DigiScope is described and its automated functions are evaluated. METHODS The DigiScope consists of a semiautomated optical head to acquire fundus images, evaluate(More)
OBJECTIVE The posterior pole ganglion cell bodies form a substantial fraction of the retinal thickness, prompting the authors to study the feasibility of detecting, by scanning retinal thickness analysis, retinal changes at the posterior pole due to glaucomatous damage. STUDY DESIGN Nonconsecutive case series. PARTICIPANTS One or both eyes of patients(More)
PURPOSE The rat has been used to generate models of various eye diseases. However, methods to study the choriocapillaris noninvasively have been inadequate in this species. Laser-targeted angiography was applied to generate local, repetitive angiograms of the choriocapillaris in the rat and to assess the similarity between the choriocapillaris of the rat(More)
OBJECTIVE Objective and sensitive measurements of the retinal thickness at the posterior pole are useful to detect and delineate macular edema or retinal atrophy. The authors therefore developed an instrument, the Retinal Thickness Analyzer (RTA), to map the retinal thickness rapidly. The RTA was used to study the normal thickness at the posterior pole and(More)
PURPOSE The authors have further developed their method of retinal thickness analysis to rapidly generate multiple optical cross sections of the retina and provide thickness maps at the posterior pole. The potential use of this method was evaluated in a number of macular disorders. METHODS A commercial prototype of the scanning retinal thickness analyzer(More)
OBJECTIVE This study aimed to examine the characteristics of intraretinal changes associated with macular holes and epiretinal membranes by scanning retinal thickness analysis. STUDY DESIGN The study design was a nonconsecutive case series. PATIENTS Fifty-six eyes of patients who had either a suspected or clinically diagnosed macular hole or epiretinal(More)
PURPOSE Laser-targeted angiography has unique advantages over conventional angiography of the fundus. Its efficacy in visualizing choroidal neovascular membranes was tested in a rat model and compared to that of fluorescein angiography. METHOD Laser-targeted angiography was performed in rats with choroidal neovascularization (CNV) by injecting(More)
PURPOSE A new method, laser-targeted photoocclusion, was developed to occlude choroidal neovascularization while minimizing damage to the overlying retina. The ability to occlude normal choriocapillary layer in rats was evaluated as a first test of the feasibility of treating choroidal neovascularization with this method. METHOD A photosensitive agent,(More)
OBJECTIVE To assess the morphologic characteristics of the foveal abnormality in juvenile X-linked retinoschisis using the scanning retinal thickness analyzer (RTA). This characteristic foveal abnormality is present in 83% to 100% of patients with X-linked retinoschisis and has not been demonstrated histopathologically. METHODS The RTA is a noncontact(More)
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