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The Complete Spectrum of Yeast Chromosome Instability Genes Identifies Candidate CIN Cancer Genes and Functional Roles for ASTRA Complex Components
TLDR
The comprehensive CIN gene list presented here in principle comprises all conserved eukaryotic genome integrity pathways and allows direct cross-referencing with tumor mutational data and thus candidate mutations potentially driving CIN in tumors.
Elg1, an alternative subunit of the RFC clamp loader, preferentially interacts with SUMOylated PCNA
TLDR
It is shown that yeast Elg1 interacts physically and genetically with PCNA, in a manner that depends on PCNA modification, and exhibits preferential affinity for SUMOylated PCNA.
ELG1, a yeast gene required for genome stability, forms a complex related to replication factor C
TLDR
Genetic data indicate that the Elg1, Ctf18, and Rad24 RFC-like complexes work in three separate pathways important for maintaining the integrity of the genome and for coping with various genomic stresses.
Proteasome Nuclear Activity Affects Chromosome Stability by Controlling the Turnover of Mms22, a Protein Important for DNA Repair
TLDR
The results demonstrate for the first time that a double strand break repair protein is a proteasome target, and thus link nuclear proteasomal activity and DSB repair.
Formation and dissociation of proteasome storage granules are regulated by cytosolic pH
Cytosolic pH is a cellular signal involved both in the glucose sensing that mediates proteasome storage granule formation and in a more general mechanism for signaling carbon source exhaustion.
The Protein Quality Control Machinery Regulates Its Misassembled Proteasome Subunits
TLDR
This work reveals how the dysfunctional proteasome is controlled by the PQC machinery, and finds that among the multilayered quality control mechanisms, UPS mediated degradation of its own misassembled subunits is the favored pathway.
Biogenesis of RNA Polymerases II and III Requires the Conserved GPN Small GTPases in Saccharomyces cerevisiae
TLDR
This study shows that the nuclear import defect of iwr1Δ, but not the GPN2 or GPN3 mutant defects, is partially suppressed by fusion of a nuclear localization signal to the RNA polymerase II subunit Rpb3, and suggests that theGPN proteins function upstream of Iwr1 in RNA polymerases II and III biogenesis.
The Elg1 Clamp Loader Plays a Role in Sister Chromatid Cohesion
TLDR
Evidence is presented that Elg1, Ctf4, and Ctf18 may coordinate the relative movement of the replication fork with respect to the cohesin ring, and that CTF18 and Elg 1 affect cohesion via a joint pathway.
An Updated Collection of Sequence Barcoded Temperature-Sensitive Alleles of Yeast Essential Genes
TLDR
This resource covers a larger gene repertoire than previous collections and provides a complementary set of strains suitable for single gene and genomic analyses and will serve as a community resource for probing new aspects of biology for essential yeast genes.
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