Shawnya J. Michaels

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The relationship between DNA cross-linking and cell killing by c;'s-diamminedichloroplatinum(ll) (c/s-DDP) and L-phenylal-anine mustard (L-PAM) was studied in L1210 cell culture lines and in mice bearing sensitive and resistant lines of L1210 leukemia. A line of L1210 mouse leukemia cells was developed which is resistant to c/s-DDP in vitro. These cells,(More)
Anti-PEG antibodies have been reported to mediate the accelerated clearance of PEG-conjugated proteins and liposomes, all of which contain methoxyPEG (mPEG). The goal of this research was to assess the role of the methoxy group in the immune responses to mPEG conjugates and the potential advantages of replacing mPEG with hydroxyPEG (HO-PEG). Rabbits were(More)
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