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Nuclear pore complexes (NPCs) gate the only conduits for nucleocytoplasmic transport in eukaryotes. Their gate is formed by nucleoporins containing large intrinsically disordered domains with multiple phenylalanine-glycine repeats (FG domains). In combination, these are hypothesized to form a structurally and chemically homogeneous network of random coils(More)
BACKGROUND Molecular dynamics (MD) simulation is a powerful technique for sampling the meta-stable and transitional conformations of proteins and other biomolecules. Computational data clustering has emerged as a useful, automated technique for extracting conformational states from MD simulation data. Despite extensive application, relatively little work(More)
Continuing improvements in algorithms and computer speeds promise that an increasing number of biomolecu-lar phenomena can be simulated by molecular dynamics to produce accurate " trajectories " of their molecular motions on the nanosecond to microsecond time scale. An important target for such simulations will be non-equilibrium biochemical processes, such(More)
We investigate publicly available geo-referenced photo collections for land cover classification. Mapping land cover is a fundamental task in the geographic sciences and is typically done using remote sensing (overhead) imagery through manual annotation. We here propose a novel alternate approach based on proximate sensing. The goal of proximate sensing is(More)
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