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Establishment of synaptic connections in the neuropils of the developing nervous system requires the coordination of specific neurite-neurite interactions (i.e., axon-axon, dendrite-dendrite and axon-dendrite interactions). The molecular mechanisms underlying coordination of neurite-neurite interactions for circuit assembly are incompletely understood. In(More)
Microbial degradation plays a substantial role in the bioremediation of persistent and toxic pollutants entering the environment as a result of human activities. Caprolactam (CAP, epsilon-caprolactam, the cyclic amide of 6-aminohexanoic acid) is one of the most saleable items on the world market of chemical products. CAP is used as a raw material for the(More)
The amino acid residues essential for the enzymatic activity of bacteriophage T5 deoxyribonucleoside monophosphate kinase were determined using a computer model of the enzyme active site. By site-directed mutagenesis, cloning, and gene expression in E. coli, a series of proteins were obtained with single substitutions of the conserved active site amino acid(More)
726 Investigation of molecular mechanisms of the emergence and outspread of the capacity of microorr ganisms for oxidation of xenobiotic compounds that had not previously existed in nature is not only imporr tant for the science of evolutionary biology, but is also of practical significance for ecology, biotechnology, and metabolic engineering. Caprolactam(More)
Five bacterial strains with the unique ability to utilize low-molecular linear caprolactam oligomers (nylon oligomers) were isolated from soil samples contaminated with industrial wastes of epsilon-caprolactam. Based on the properties studied and also on the analysis of 16S rRNA gene nucleotide sequences, the strains BS2, BS3, BS9, BS38, and BS57 were(More)
INTRODUCTION Today, paramedics employ one of two different forms of treatment when providing care to trauma victims at the site of an accident. One of these practices involves administering as much medical care as possible to casualties at the trauma site itself, and is the dominant mode of pre-clinical treatment offered in most European countries. The(More)
The number of patients starting dialysis is increasing world wide. Unplanned dialysis starts (patients urgently starting dialysis in hospital) is associated with increased costs and high morbidity and mortality. Risk factors for starting dialysis urgently in hospital have not been well studied. The primary objective of this study was to identify risk(More)
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