Shaurya Prakash

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This paper demonstrates a chemical surface modification method for covalent attachment of various polymers by using silane-based "click" chemistry on silica surfaces and within glass microchannels suitable for CE systems. Modified surfaces are characterized by contact angle measurements, X-ray photoelectron spectroscopy, and Fourier transform(More)
Biosensors are a broad array of devices that detect the type and amount of a biological species or biomolecule. Several different types of biosensors have been developed that rely on changes to mechanical, chemical or electrical properties of the transduction or sensing element to induce a measurable signal. Often, a biosensor will integrate several(More)
Solid-state nanopores and nanocapillaries find increasing use in a variety of applications including DNA sequencing, synthetic nanopores, next-generation membranes for water purification, and other nanofluidic structures. This paper develops the use of electrochemical impedance spectroscopy to determine the geometry of nanocapillaries. A network equivalent(More)
Microfluidic and nanofluidic systems are dominated by fluid-wall interactions due to enormous surface-area-to-volume ratios in these devices. Therefore, strategies to control wall properties in a reliable and repeatable manner can be important for device operation. Chemical modification of surfaces provides one such method. However, the stability of the(More)
Separation rates and resolutions within capillary electrophoretic (CE) systems can be enhanced when surface zeta potentials are uniform with minimum deviations from ideal pluglike flow. Microfluidic CE devices based on poly(methyl methacrylate) (PMMA) are being developed due to the optical clarity, availability, stability, and reproducible electroosmotic(More)
Since the 1990s, there has been a growing interest in developing microscale lab-on-a-chip systems for bio-detection, biotechnology, chemical and biological reactors, and medical, pharmaceutical, and environmental monitoring (Prakash et al. 2012; Swaminathan et al. 2012; Guan et al. 2014). The success of microfluidic lab-on-a-chip devices is due to the(More)
We report a three-state nanofluidic field effect switch in an asymmetrically gated device with a forward (positive), off (zero), and a reverse (negative) current state for tunable control of ionic transport by systematically controlling the gate potential. The embedded gate electrode allows for modulation of the ionic current through the 16 nm deep channels(More)
Past research has confirmed the existence of surface nanobubbles on various hydrophobic substrates (static contact angle >90°) when imaged in air-equilibrated water. Additionally, the use of solvent exchange techniques (based on the difference in saturation levels of air in various solvents) also introduced surface nanobubbles on hydrophilic substrates(More)
Nanoscale fluid transport through conduits in the 1-100 nm range is termed as nanofluidics. Over the past decade or so, significant scientific and technological advances have occurred in the domain of nanofluidics with a transverse external electrical signal through a dielectric layer permitting control over ionic and fluid flows in these nanoscale(More)