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Biosynthesis of the neurotoxin domoic acid in a bloom-forming diatom
How algae turn tides toxic Algal blooms can devastate marine mammal communities through the production of neurotoxins that accumulate within the food web. Brunson et al. identified a cluster of genesExpand
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Scalable Biosynthesis of the Seaweed Neurochemical, Kainic Acid.
Kainic acid, the flagship member of the kainoid family of natural neurochemicals, is a widely used neuropharmacological agent that helped unravel the key role of ionotropic glutamate receptors,Expand
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Total Synthesis Establishes the Biosynthetic Pathway to the Naphterpin and Marinone Natural Products.
The naphterpins and marinones are naphthoquinone meroterpenoids with an unusual aromatic oxidation pattern that is biosynthesized from 1,3,6,8-tetrahydroxynaphthalene (THN). We propose that crypticExpand
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Biosynthesis of l-4-Chlorokynurenine, an Antidepressant Prodrug and a Non-Proteinogenic Amino Acid Found in Lipopeptide Antibiotics.
l-4-Chlorokynurenine (l-4-Cl-Kyn) is a neuropharmaceutical drug candidate that is in development for the treatment of major depressive disorder. Recently, this amino acid was naturally found as aExpand
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Macrocyclic colibactin induces DNA double-strand breaks via copper-mediated oxidative cleavage
Colibactin is an as-yet-uncharacterized human gut bacterial genotoxin, whose biosynthesis is linked to clb genomic island that distributes widespread in pathogenic and commensal human enterobacteria.Expand
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Solid-supported synthesis and biological evaluation of the lantibiotic peptide bis(desmethyl) lacticin 3147 A2.
Lantibiotics are a class of bacteriocins (antimicrobial peptides from bacteria) that undergo extensive post-translational processing. Their biosynthesis involves enzymatic dehydration of serineExpand
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The synthesis of active and stable diaminopimelate analogues of the lantibiotic peptide lactocin S.
Lantibiotic peptides are potent antimicrobial compounds produced by Gram-positive bacteria. They can be used in food preservation, and some also show potential for clinical applications.Expand
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Characterization and Biochemical Assays of Streptomyces Vanadium-Dependent Chloroperoxidases.
Vanadium-dependent haloperoxidases (VHPOs) are fascinating enzymes that facilitate electrophilic halogen incorporation into electron-rich substrates, simply requiring vanadate, a halide source, andExpand
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Total Enzyme Syntheses of Napyradiomycins A1 and B1.
The biosynthetic route to the napyradiomycin family of bacterial meroterpenoids has been fully described 32 years following their original isolation and 11 years after their gene cluster discovery.Expand
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The solid phase supported peptide synthesis of analogues of the lantibiotic lactocin S
Four analogues of lactocin S, an antimicrobial lantibiotic peptide produced by Lactobacillus sakei L45, have been generated using solid-phase peptide chemistry. These analogues serve a dual purposeExpand
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