Shashi Ravi

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Four cases of acute proctocolitis associated with non-steroidal anti-inflammatory drug therapy are presented. The drugs implicated were flufenamic acid, mefenamic acid, naproxen and ibuprofen. After resolution of symptoms and signs of proctocolitis three of the four patients were subsequently rechallenged with the implicated drug: in each there was a rapid(More)
The prodrug approach has become an extensive tool to prevent a myriad of undesirable biopharmaceutical properties like minimal oral absorption, permeability, toxicity, and excessive first pass metabolism, physicochemical properties like poor solubility, chemical instability, bad odour or taste, or pharmacodynamic properties like irritation or pain and(More)
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