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Background: Retinoic acid plays an important role in lung development and differentiation, acting primarily via nuclear receptors encoded by the retinoic acid receptor-␤ (RAR␤) gene. Because receptor isoforms RAR␤2 and RAR␤4 are repressed in human lung cancers, we investigated whether methylation of their promoter, P2, might lead to silencing of the RAR␤(More)
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