Sharvari Kulkarni

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The Topoisomerase I enzyme has become an attractive target for the treatment of cancer. In this paper molecular dynamics, 2D and 3D QSAR and molecular docking studies were performed on 90 naphthoquinone derivatives as Topoisomerase I inhibitors by using the human Topo I-DNA cleavable complex. This model has the drug intercalated with its planar(More)
The traditional risk management literature is oriented towards preventing and decreasing the impact of a crisis on an organization’s Business Continuity (BC). This is generally done by identifying, analyzing and assessing the impact that certain anticipated risks would have on the organization. In contrast, there is a relative dearth of literature on what(More)
Khardenavis V, et al. BMJ Case Rep 2017. doi:10.1136/bcr-2017-221328 Description A 23-year-old woman with no premorbid illness presented with features of high-grade fever since 3 days. She developed progressively deteriorating sensorium, recurrent vomiting and multiple episodes of generalised tonic clonic seizures. On examination, funduscopy was normal. The(More)
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