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Evaluation of the Transwell System for Characterization of Dissolution Behavior of Inhalation Drugs: Effects of Membrane and Surfactant.
- Marc Rohrschneider, Sharvari Bhagwat, R. Krampe, V. Michler, J. Breitkreutz, G. Hochhaus
- Chemistry, Medicine
- Molecular pharmaceutics
- 9 July 2015
Assessing the dissolution behavior of orally inhaled drug products (OIDs) has been proposed as an additional in vitro test for the characterization of innovator and generic drug development. A number… Expand
Predicting Pulmonary Pharmacokinetics from In Vitro Properties of Dry Powder Inhalers
PurposeThe ability of two semi-mechanistic simulation approaches to predict the systemic pharmacokinetics (PK) of inhaled corticosteroids (ICSs) delivered via dry powder inhalers (DPIs) was assessed… Expand
Characterization of clinical pharmacokinetics and exposure-response relationships of AMG 330, a bispecific CD33 T-cell engager antibody construct, in patients with relapsed/refractory AML.
7536Background: AMG 330 binds both CD33 and CD3 and redirects T cells toward CD33+ cells leading to T-cell‒mediated cytotoxicity against AML blasts. An ongoing open label phase I dose-escalation st...