Sharul Hashim

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OBJECTIVE Blunt traumatic aortic injury (BTAI) is part of a spectrum of diseases termed acute aortic syndrome that accounts for 20% of road traffic accident related deaths. The injury has a complex aetiology with a number of putative mechanisms accounting for the injury profile, characteristics of which include a transverse primary intimal tear located at(More)
Essential oils from common spices such as nutmeg, ginger, cardamom, celery, xanthoxylum, black pepper, cumin, and coriander were tested for their ability to suppress the formation of DNA adducts by aflatoxin B1 in vitro in a microsomal enzyme-mediated reaction. All oils were found to inhibit adduct formation very significantly and in a dose-dependent(More)
The present study deals with the chemopreventive action of the food-seasoning spices mixture Garam masala on dimethylbenz[a]anthracene (DMBA)-induced translactational and transplacental carcinogenesis in mice. When pregnant mice were given 10 and 30 mg of Garam masala per day from Days 13-19 of gestation in addition to DMBA (5 mg/day) on Days 15-17 of(More)
BACKGROUND Patients undergoing mitral valve repair (MVRr) are often discharged on oral anticoagulation with warfarin. Because the decision about oral anticoagulation is made at discharge from the hospital and because atrial fibrillation (AF) represents the only well-documented indication for oral anticoagulation in these patients, we studied the frequency(More)
An elderly lady with severe aortic stenosis presented with profuse bleeding per rectum, secondary to angiodysplasia of the small intestine. An emergency aortic valve replacement with a bioprosthesis led to the resolution of her symptoms. Although the association of aortic stenosis and angiodysplasia have been described previously, the patho-physiological(More)
The present study reports the chemopreventive potential of the oil from mustard seed on 7,12-dimethylbenz[a]anthracene-induced transplacental and translactational carcinogenesis in Swiss albino mice. Gestating females were treated with mustard oil at dose levels of 0.05 and 0.10 ml per day from days 13 to 19 of gestation. In addition, they were given DMBA(More)
The present study examines the transmammary modulation of the glutathione system of enzymes in the F1 generation of mouse pups postnatally exposed to malathion. Lactating Swiss albino mice received either 30 or 100 mg malathion kg-1 body wt. (98% pure) for 14 or 21 days postpartum. The acid-soluble sulphydryl content was significantly increased (P < 0.001)(More)
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