Sharon Zlochiver

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In pathological conditions such as ischemic cardiomyopathy and heart failure, differentiation of fibroblasts into myofibroblasts may result in myocyte-fibroblast electrical coupling via gap junctions. We hypothesized that myofibroblast proliferation and increased heterocellular coupling significantly alter two-dimensional cardiac wave propagation and(More)
Fibroblasts make for the most common nonmyocyte cells in the human heart and are known to play a role in structural remodeling caused by aging and various pathological states, which can eventually lead to cardiac arrhythmias and fibrillation. Gap junction formed between fibroblasts and myocytes have been recently described and were shown to alter the(More)
In electrical impedance tomography (EIT), measurements of developed surface potentials due to applied currents are used for the reconstruction of the conductivity distribution. Practical implementation of EIT systems is known to be problematic due to the high sensitivity to noise of such systems, leading to a poor imaging quality. In the present study, the(More)
AIMS The goal was to terminate atrial fibrillation (AF) by targeting atrioventricular differences in ionic properties. METHODS AND RESULTS Optical mapping was used to record electrical activity during carbachol (0.25-0.5 μM)-induced AF in pig hearts. The atrial-specific current, I(Kur), was blocked with 100 μM 4-aminopyridine (4-AP) or with 0.5 μM DPO-1.(More)
Ectopic activity in multiple sclerosis (MS) patients has been traditionally attributed to hyperexcitability of the demyelinated axon segments. Here, we propose that the same outcome may be the result of persistent reflection--the continuous reactivation of the axonal nodes that limit a demyelinated internodal segment. Using computer simulations, we studied(More)
Aims. The goal was to terminate atrial fibrillation (AF) by targeting atrio-ventricular differences in ionic properties. Methods. Optical mapping was used to record electrical activity during carbachol (0.25-0.5µM)-induced AF in pig hearts. The atrial specific current, I Kur , was blocked with 100 µM 4-aminopyridine (4-AP) or 0.5 µM DPO-1. Hearts in AF and(More)
Electrogram-guided ablation has been recently developed for allowing better detection and localization of abnormal atrial activity that may be the source of arrhythmogeneity. Nevertheless, no clear indication for the benefit of using electrograms guided ablation over empirical ablation was established thus far, and there is a clear need of improving the(More)
The accurate navigation and location of a biopsy needle is of main clinical interest in cases of image-guided biopsies for patients with suspected cancerous lesions. Magnetic induction (MI) imaging is a relatively new simple and low-cost noninvasive imaging modality that can be used for measuring the changes of electrical conductivity distribution inside a(More)
In the noninvasive bio-impedance technique, small amplitude currents are applied to the body and the developing potentials on its surface are measured. This noninvasive technique is used to monitor physiological and pathological processes, which alter the values or the spatial distribution of the electrical impedance inside the human body. A possible(More)