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In pathological conditions such as ischemic cardiomyopathy and heart failure, differentiation of fibroblasts into myofibroblasts may result in myocyte-fibroblast electrical coupling via gap junctions. We hypothesized that myofibroblast proliferation and increased heterocellular coupling significantly alter two-dimensional cardiac wave propagation and(More)
Heart failure (HF) commonly results in atrial fibrillation (AF) and fibrosis, but how the distribution of fibrosis impacts AF dynamics has not been studied. HF was induced in sheep by ventricular tachypacing (220 bpm, 6 to 7 weeks). Optical mapping (Di-4-ANEPPS, 300 frames/sec) of the posterior left atrial (PLA) endocardium was performed during sustained AF(More)
AIMS The goal was to terminate atrial fibrillation (AF) by targeting atrioventricular differences in ionic properties. METHODS AND RESULTS Optical mapping was used to record electrical activity during carbachol (0.25-0.5 μM)-induced AF in pig hearts. The atrial-specific current, I(Kur), was blocked with 100 μM 4-aminopyridine (4-AP) or with 0.5 μM DPO-1.(More)
Maintenance of paroxysmal atrial fibrillation (AF) by fast rotors near or at the pulmonary veins (PVs) is not fully understood. We believe that heterogeneous distribution of transmembrane currents in the PVs and LA junction (PV-LAJ) play a major in the localization of rotors in the PVs. We seek for pacing protocols and measurements that could be used to(More)
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