Sharon Mackinnon

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Extracts of 22 species of Meliaceae were examined for antimalarial activity using in vitro tests with two clones of Plasmodium falciparum, one sensitive to chloroquine (W2) and one chloroquine-resistant (D6). Twelve extracts were found to have activity, including extracts of Cedrela odorata wood and Azadirachta indica leaves, which contained the limonoid(More)
A quantitative ethnobotanical approach to antimalarial drug discovery led to the identification of Lansium domesticum Corr. Ser. (Meliaceae) as an important antimalarial used by Kenyah Dyak healers in Indonesian Borneo. Triterpenoid lansiolides with antimalarial activity were isolated from the bark and shown to have activity in both in vitro bioassays with(More)
BACKGROUND Chlamydia trachomatis is a common, often asymptomatic sexually transmitted infection. GOAL The goal was to estimate the prevalence and predictors of C. trachomatis among young women using self-collected vaginal swabs, and the preferences of women and physicians for self-testing. STUDY DESIGN A total of 514 attendees of university/college(More)
The magnitude of the overall prevalence and racial disparity in induced abortion suggests that it is a major influence on the demographic and socioeconomic composition of the population of the United States (US). However, the years of potential lives averted by induced abortion have not been systematically studied. We applied race-specific intra-uterine(More)
There is no credible scientific opposition to the fact that a genetically distinct human life begins at conception and that an induced abortion is a death. Yet, abortion is not reported as a cause of death in the U.S. vital statistics system. Mortality patterns have profound implications for public policy. As a cause of death, we found abortion to be highly(More)
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