Sharon Janssens

Learn More
Insulin resistance is associated with ectopic lipid accumulation. Physical activity improves insulin sensitivity, but the impact of exercise on lipid handling in insulin-resistant tissues remains to be elucidated. The present study characterizes the effects of acute exercise on lipid content and dietary lipid partitioning in liver and skeletal muscle of(More)
The development of new diagnostic criteria for Alzheimer's disease (AD) requires new in vivo markers reflecting early pathological changes in the brain of patients. Magnetic resonance (MR) spectroscopy has been shown to provide useful information about the biochemical changes occurring in AD brain in vivo. The development of numerous transgenic mouse models(More)
We aimed to elucidate the effects of caloric and non-caloric sweeteners on liver lipid metabolism in rats using in vivo magnetic resonance spectroscopy (MRS) and to determine their roles in the development of liver steatosis. Wistar rats received normal chow and either normal drinking water, or solutions containing 13% (w/v) glucose, 13% fructose, or 0.4%(More)
BACKGROUND Excess consumption of energy-dense, high-fat Western diets contributes to the development of obesity and obesity-related disorders, such as fatty liver disease. However, not only the quantity but also the composition of dietary fat may play a role in the development of liver steatosis. The aim of this study was to determine the effects of(More)
1 lean and diabetic rats 2 3 Sharon Janssens*, Richard A.M. Jonkers*, Albert K. Groen, Klaas Nicolay, Luc J.C. van Loon, 4 and Jeanine J. Prompers 5 6 * Authors contributed equally 7 8 Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, 9 Eindhoven, The Netherlands; The Netherlands Consortium for Systems Biology, Den(More)
  • 1