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  • Mary Ann O’Donnell, Yuchun Luo, Xiaohong Chen, A Szilvasi, Sharon E. Hunter, Steven K. Clinton
  • Biology, Medicine
  • Journal of immunology
  • 1999 (First Published: 15 October 1999)
  • Although Mycobacterium bovis bacillus Calmette-Guérin (BCG) has been accepted as the most effective agent in clinical use against superficial bladder cancer, its mechanism of action remainsContinue Reading
  • Sharon E. Hunter, K E Waldburger, D K Thibodeaux, Robert G. Schaub, Samuel J. Goldman, John P. Leonard
  • Biology, Medicine
  • European journal of immunology
  • 1997 (First Published: 1 December 1997)
  • Administration of recombinant murine interleukin (rmIL)-12 to MB49.1 tumor-bearing mice results in dose-dependent regression of the primary tumor and the generation of protective antitumor immunityContinue Reading
  • Michael O'Donnell, Yi Luo, Sharon E. Hunter, Xiaohong Chen, Lori L Hayes, Steven K. Clinton
  • Medicine
  • The Journal of urology
  • 2004 (First Published: 1 March 2004)
  • PURPOSE The antitumor activity of interleukin (IL)-12 has been demonstrated in a number of tumor models but barely tested in bladder cancer models. We evaluated the antibladder cancer activity ofContinue Reading
  • D K Thibodeaux, Sharon E. Hunter, +6 authors John P. Leonard
  • Biology, Medicine
  • Journal of immunology
  • 1999 (First Published: 15 November 1999)
  • The biological response to IL-12 is mediated through specific binding to a high affinity receptor complex composed of at least two subunits (designated IL-12Rbeta1 and IL-12Rbeta2) that are expressedContinue Reading
  • L H Donnelly, Mark P. van Bree, Sharon E. Hunter, James C. Keith, Robert G. Schaub
  • Biology, Medicine
  • Molecular reproduction and development
  • 1997
  • Infiltration of monocytes into arteries is an early event in the pathogenesis of atherosclerosis. This recruitment is interpreted as enhancing lesion development, but it could also be a host responseContinue Reading
  • Michael O'Donnell, Yi Luo, Sharon E. Hunter, Xiaohong Chen, Lori L Hayes, Steven K. Clinton
  • Medicine
  • The Journal of urology
  • 2004 (First Published: 1 March 2004)
  • PURPOSE Recombinant interleukin (IL)-12 and adenoviral IL-12 gene therapy have been shown to be potent therapeutic interventions for murine transitional cell carcinoma (TCC) of the bladder in vivo.Continue Reading