Sharon A Takiguchi

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OBJECTIVE To investigate the relationship of mortality to early resuscitation using two levels of oxygen delivery (DO2) in critically ill surgical patients > or =50 yrs of age who were stratified into groups: age < or =75 yrs (age 50 to 75 yrs group); and age >75 yrs (age >75 yrs group). DESIGN A prospective, randomized trial, continued from a previous(More)
OBJECTIVES To determine the frequency of myocardial infarction and mortality during treatment that increased oxygen delivery (DO2) to > or = 600 mL/min/m2. To define the characteristics of patients achieving a high DO2 without inotropes in order to guide future studies. DESIGN A prospective, randomized, controlled trial. SETTING Two surgical intensive(More)
OBJECTIVE To evaluate the agreement of continuous cardiac output and mixed venous oxygen saturation measurements, obtained with a modified pulmonary artery catheter, with those values obtained by standard intermittent bolus thermodilution and cooximetry. DESIGN Prospective, clinical investigation. SETTING A surgical intensive care unit in a tertiary(More)
OBJECTIVE To determine the clinical impact and cost-effectiveness of two lateral rotation low air-loss therapy beds and their supporting protocols in the treatment of critically ill patients. DESIGN Retrospective-cohort (2:1 design) study consisting of chart reviews of patients on two types of lateral rotation low air-loss therapy and their protocols from(More)
Measurement of blood volume (BV) may guide fluid and red blood cell management in critically ill patients when capillary leak from shock and fluid resuscitation makes assessment of intravascular volume difficult. This is a prospective randomized trial of critically ill surgical patients with septic shock, severe sepsis, severe respiratory failure, and/or(More)
OBJECTIVE To determine if treatment modalities (fluid, inotropes, and blood) would be altered based on preload measurements of right ventricular end-diastolic volume index measured by fast response thermodilution catheter, as compared with pulmonary artery occlusion pressure (PAOP). DESIGN A prospective clinical trial. SETTING An 11-bed surgical(More)
Nutritional support is essential to the care of the critically ill patient, but complications of overfeeding can occur. Precise metabolic measurement by indirect calorimetry can detect problems of nutrition and allow adjustment in caloric intake. This case study illustrates the complications of carbon dioxide retention and inability to wean from mechanical(More)
OBJECTIVE To determine the effects of optimizing oxygen delivery (DO2) to "supranormal" levels on morbidity and mortality in patients with sepsis, septic shock, and adult respiratory distress syndrome. DESIGN A prospective, randomized, controlled trial. SETTING A 16-bed surgical intensive care unit (ICU) and 14-bed mixed medical/surgical ICU in two(More)