Sharmishtaa Seshamani

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Capsule endoscopy (CE) provides noninvasive access to a large part of the small bowel that is otherwise inaccessible without invasive and traumatic treatment. However, it also produces large amounts of data (approximately 50,000 images) that must be then manually reviewed by a clinician. Such large datasets provide an opportunity for application of image(More)
A variety of pixel and feature based methods have been proposed for registering multiple views of anatomy visible in studies obtained using diagnostic, minimally invasive imaging. A given registration method may outperform another depending on anatomical variations, imaging conditions, and imaging sensor performance, and it is often difficult a priori to(More)
This paper presents a method for intensity inhomogeniety removal in fMRI studies of a moving subject. In such studies, subtle changes in signal as the subject moves in the presence of a bias field can be a significant confound for BOLD signal analysis. The proposed method avoids the need for a specific tissue model or assumptions about tissue homogeneity by(More)
Wireless capsule endoscopy (CE) is increasing being used to assess several gastrointestinal(GI) diseases and disorders. Current clinical methods are based on subjective evaluation of images. In this paper, we develop a method for ranking lesions appearing in CE images. This ranking is based on pairwise comparisons among representative images supplied by an(More)
This paper presents an approach to 3-D diffusion tensor image (DTI) reconstruction from multi-slice diffusion weighted (DW) magnetic resonance imaging acquisitions of the moving fetal brain. Motion scatters the slice measurements in the spatial and spherical diffusion domain with respect to the underlying anatomy. Previous image registration techniques have(More)
Recently, there has been considerable interest, especially for in utero imaging, in the detection of functional connectivity in subjects whose motion cannot be controlled while in the MRI scanner. These cases require two advances over current studies: (1) multiecho acquisitions and (2) post processing and reconstruction that can deal with significant(More)
Statistical atlases of bone anatomy are traditionally constructed with point-based models. These methods establish initial point correspondences across the population of shapes and model variations in the shapes using a variety of statistical tools. A drawbacks of such methods is that initial point correspondences are not updated after their first(More)
PURPOSE Maximization of the blood oxygen level-dependent (BOLD) functional MRI (fMRI) contrast requires the echo time of the MR sequence to match the T2* value of the tissue of interest, which is expected to be higher in the fetal brain compared with the brain of a child or an adult. METHODS T2* values of the cortical plate/cortical gray matter tissue in(More)