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Lateral ventricular volumes were measured on magnetic resonance imaging (MRI) scans by independent raters in 18 subjects (11 psychotic patients and 7 healthy control subjects) with two different approaches: a point-counting stereological (PCS) technique and a computerized technique based on segmentation algorithms. The correlation between the two techniques(More)
Several lines of evidence support the notion that a substantial reorganization of cortical connections, involving a programmed synaptic pruning, takes place during adolescence in humans. A review of neurobiological abnormalities in schizophrenia indicates that the neurobiological parameters that undergo peripubertal regressive changes may be abnormal in(More)
BACKGROUND Studies in schizophrenic patients have reported dopaminergic abnormalities in striatum, substantia nigra, thalamus, anterior cingulate, hippocampus, and cortex that have been related to positive symptoms and cognitive impairments. METHODS [(18)F]fallypride positron emission tomography studies were performed in off-medication or never-medicated(More)
A dysfunction of pursuit eye tracking in psychiatric patients has been well documented, but its cause has not. Recent speculation implicates a pathological disinhibition of saccades in these patients. However, great variability in tracking performance was found among nine normal subjects, and tracking quality improved in each when asked to perform a simple(More)
A pilot study was undertaken to monitor the use of psychotropic drugs in a psychiatric hospital unit and a comparable acute medical unit together with their out-patient clinics, during a 2 month period. Both units served the same catchment area. Using the DDD (defined daily dose) for each class of drug, an index was calculated as an indicator of usage. An(More)
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